{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T18:32:05Z","timestamp":1775327525311,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>Histiocytes and dendritic cells may display cytological atypia and an aberrant immunophenotype even in reactive processes. Herein, we describe two cases of \u201cHodgkinoid histiocytosis\u201d that show distinctive clinicopathological features, mimicking morphologically classic Hodgkin lymphoma (CHL), but suggesting reactive histiocytic\/dendritic cell proliferation in lymph nodes. Both the patients presented with peripheral lymphadenopathy and blood eosinophilia with skin manifestations. Lymph node biopsy revealed scattered large histiocytes resembling Hodgkin cells with a round or stellate shape, abundant cytoplasm, and distinct nucleoli admixed in a predominant inflammatory background. The Hodgkinoid histiocytes occasionally showed emperipolesis. They expressed CD30, S100, and PD\u2010L1 proteins but lacked PAX5 and CD1a expressions, Epstein\u2013Barr association, <jats:italic>BRAF<\/jats:italic> V600E mutation, and <jats:italic>PD\u2010L1<\/jats:italic> gene amplification. Neither of the patients showed overt progression to malignant haematopoietic neoplasms during the disease course. An identical case series of four patients has been reported to date. Both these series highlight the potential of being interpreted as CHL due to the presence of Hodgkinoid histiocytes with CD30 positivity.<\/jats:p>","DOI":"10.1111\/his.14718","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T11:09:47Z","timestamp":1657019387000},"page":"371-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hodgkinoid histiocytosis: an atypical nodal <scp>CD30<\/scp> and <scp>S100<\/scp>\u2010positive histiocytosis with eosinophilia"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8718-4599","authenticated-orcid":false,"given":"Naoko","family":"Tsuyama","sequence":"first","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reimi","family":"Asaka","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology project for molecular targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology project for molecular targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Baba","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology project for molecular targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Pathology Juntendo University Urayasu Hospital  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-5800","authenticated-orcid":false,"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology project for molecular targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.11.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13795"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0380-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3087"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"e_1_2_10_8_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues, revised 4th edition","author":"Swerdlow SHCE","year":"2017"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-772632"},{"key":"e_1_2_10_10_1","first-page":"7531729","article-title":"PAX5\u2010negative classical hodgkin lymphoma: a case report of a rare entity and review of the literature","volume":"2017","author":"Vali Betts E","year":"2017","journal-title":"Case Rep. 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