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Lesions occurring prior to STIC within the carcinogenic sequence for the pathogenesis of invasive high\u2010grade serous carcinoma include the p53 signature and secretory cell outgrowth (SCOUT). Variable histological criteria have been used for diagnosing STIC, but a combination of morphology and immunohistochemistry for p53\/Ki\u201067 improves interobserver agreement. Half of all carcinomas identified in risk\u2010reducing salpingo\u2010oophorectomy specimens are in the form of STIC; however, STIC also may be incidentally found on occasion in specimens from women at low or average risk of ovarian\/tubal\/peritoneal carcinoma. <jats:italic>TP53<\/jats:italic> mutation is the earliest known DNA sequence alteration in STIC and almost all invasive high\u2010grade serous carcinomas of the ovary and peritoneum. Data on the clinical behaviour of STIC are limited. While the short\u2010term follow\u2010up in the prior literature suggests a low risk of malignant progression, a more recent meta\u2010analysis indicates a 10\u2010year risk of 28%. STIC probably should be best regarded as a lesion with uncertain malignant potential at present, and future molecular analysis will help to classify those with higher risk of dissemination. This review provides an update on the current knowledge of STIC and related issues.<\/jats:p>","DOI":"10.1111\/his.14722","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T04:50:51Z","timestamp":1658379051000},"page":"542-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<scp>Serous tubal intra\u2010epithelial carcinoma<\/scp>: what do we really know at this point?"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-7743","authenticated-orcid":false,"given":"Russell","family":"Vang","sequence":"first","affiliation":[{"name":"Departments of Pathology (Division of Gynecologic Pathology) The Johns Hopkins Hospital  Baltimore MD USA"},{"name":"Gynecology and Obstetrics The Johns Hopkins Hospital  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie\u2010Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Departments of Pathology (Division of Gynecologic Pathology) The Johns Hopkins Hospital  Baltimore MD USA"},{"name":"Gynecology and Obstetrics The Johns Hopkins Hospital  Baltimore MD USA"},{"name":"Oncology The Johns Hopkins University School of Medicine  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.238"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2020.09.006"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10120468"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.11.033"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46334-6_11"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03244-w"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2091"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e31814b191f"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000590"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000650"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000123"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.3023"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.53"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001713"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31824cbeb4"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825ec07a"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181c713a8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31823b8831"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822f58bc"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000604"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12046"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2155"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02850.x"},{"key":"e_1_2_13_25_1","volume-title":"Female Genital Tumours. 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