{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:24:25Z","timestamp":1790267065088,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,7]],"date-time":"2022-08-07T00:00:00Z","timestamp":1659830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>Prostatic malakoplakia (MP) is rare, with only case reports and small series (&lt;\u2009five patients) available in the literature. In this study we analysed an international multi\u2010institutional series of 49 patients with prostatic MP to more clearly define its clinicopathological features. The median age was 67\u2009years and the median serum prostate\u2010specific antigen (PSA) was 7.5\u2009ng\/ml. MP was clinically manifest in most cases (28 of 45 patients with data available, 62%). Of 43 patients with detailed clinical history available, 21 (49%) had concurrent or metachronous malignancies (including prostate cancer). Diabetes or insulin resistance was present in 11 patients (26%). Additionally, three patients had a history of solid organ transplantation and one had HIV. Of note, six of 34 patients (18%) without concurrent prostate cancer had an abnormal digital rectal examination and\/or lesions on magnetic resonance imaging (MRI) with prostate imaging reporting and\u2009data system (PIRADS) scores 4\u20135. The initial diagnosis was made on core biopsies (25 of 49, 51%), transurethal resection specimens (12 of 49, 24%), radical prostatectomies (10 of 49, 20%), Holmium\u2010laser enucleation (one of 49, 2%) and cystoprostatectomy (one of 49, 2%). Tissue involvement was more commonly diffuse or multifocal (40 of 49, 82%). Von Kossa and periodic acid\u2010Schiff stains were positive in 35 of 38 (92%) and 26 of 27 lesions (96%), respectively. Of note, two cases were received in consultation by the authors with a preliminary diagnosis of mesenchymal tumour\/tumour of the specialised prostatic stroma. The present study suggests that prostatic MP is often associated with clinical findings that may mimic those of prostate cancer in a subset of patients. Moreover, MP may be found incidentally in patients with concurrent prostate cancer.<\/jats:p>","DOI":"10.1111\/his.14729","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T14:10:15Z","timestamp":1658758215000},"page":"520-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prostatic malakoplakia: clinicopathological assessment of a multi\u2010institutional series of 49 patients"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-5911","authenticated-orcid":false,"given":"Andres M","family":"Acosta","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-8964","authenticated-orcid":false,"given":"Ankur 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Pathology and Laboratory Medicine of Emory University Hospital Emory University  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Indiana University Health and Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7610-7769","authenticated-orcid":false,"given":"Hiroshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of University of Rochester Medical Center  NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Brigham and Women's Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-4004","authenticated-orcid":false,"given":"Emily","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of UCSF Medical Center University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-9638","authenticated-orcid":false,"given":"Maria","family":"Tretiakova","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of UW Medicine University of Washington  Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambit K","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of CORE Diagnostics  Gurgaon USA"},{"name":"Department of Pathology and Laboratory Medicine of Advanced medical Research Institute  Bhubaneswar USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Massachusetts General Hospital Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Aron","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Keck School of Medicine University of Southern California  Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-1267","authenticated-orcid":false,"given":"Gabriela","family":"Quiroga\u2010Garza","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of University of Pittsburgh Medical Center University of Pittsburgh  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Henry Ford Hospital  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane K","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine of Cleveland Clinic  Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-1460","authenticated-orcid":false,"given":"Sean 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