{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:58:34Z","timestamp":1785869914919,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To raise awareness of the existence of extrarenal renal cell carcinoma (RCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We report three patients with extrarenal RCC found in the renal proximity, but unattached to the kidney. None had a history of RCC or an identifiable primary renal neoplasm at the time of the diagnosis and on follow\u2010up. The patients included two males and one female aged 57, 77, and 63\u2009years, respectively. One carcinoma was found in the perirenal tissue adjacent to the adrenal, one involved the adrenal gland, and one was a retroperitoneal mass found within the lymph nodes. Two extrarenal RCCs represented clear\u2010cell RCCs and one was an unclassifiable RCC. No patient had evidence of metastases at presentation and disease progression during the follow\u2010up. This report adds to the literature on this unusual clinical scenario and further supports the concept of extrarenal RCC, which is not a well\u2010recognized clinical phenomenon. We also reviewed other similar reports documenting the absence of identifiable renal primaries in the setting of either disseminated metastatic disease or isolated distant metastases of presumed renal origin. Similarly, some carcinomas of apparent renal derivation have been also identified during a work\u2010up of metastatic carcinomas of unknown primary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There should be an awareness of this unusual and intriguing clinical scenario that currently lacks a definitive explanation and standardized therapy strategies. Establishing a correct diagnosis may allow treatment with specific targeted therapies in selected clinical cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14736","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T03:48:27Z","timestamp":1660016907000},"page":"635-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extrarenal renal cell carcinoma arising in the kidney proximity but without an identifiable renal primary \u2013 an intriguing dilemma: report of three cases and review of the literature"],"prefix":"10.1111","volume":"81","author":[{"given":"Mehdi","family":"Mansoor","sequence":"first","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Young\u2010Speirs","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Dartmouth\u2010Hitchcock Medical Center Geisel School of Medicine at Dartmouth  Lebanon New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Gotto","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Merten","sequence":"additional","affiliation":[{"name":"Department of Urology and Pediatric Urology, University Hospital Erlangen Friedrich Alexander University (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summit","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Siadat","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-6331","authenticated-orcid":false,"given":"Andres M","family":"Acosta","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-8161","authenticated-orcid":false,"given":"Abbas","family":"Agaimy","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Institute of Pathology, Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg University Hospital  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8846","authenticated-orcid":false,"given":"Kiril","family":"Trpkov","sequence":"additional","affiliation":[{"name":"Cumming School of Medicine University of Calgary and Alberta Precision Laboratories  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02780.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7796.162219"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2018.10.039"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496279"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000576"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/iju.IJU_229_20"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjaa227"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/KCA-200102"},{"key":"e_1_2_11_10_1","first-page":"50","article-title":"Papillary renal cell carcinoma presented with supraclavicular lymph node metastasis without renal primary lesion","volume":"4","author":"Thamcharoen N","year":"2013","journal-title":"World J. 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