{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T13:23:31Z","timestamp":1778073811174,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Olmesartan, an angiotensin receptor blocker (ARB) used for hypertension management, is known to cause a sprue\u2010like enteropathy in a subset of patients. Rare cases of gastritis occurring with ARB use have also been reported, but the histological features of ARB\u2010induced gastritis and the response to drug cessation have not been examined in a dedicated case\u2010series.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Cases of suspected ARB\u2010induced gastritis were identified from the pathology archives of four institutions. Haematoxylin and eosin (H&amp;E) slides from gastric biopsies were reviewed. Fifteen patients (14 female, one male) were identified. The most common presenting symptoms were diarrhoea (10) and weight loss (six). Gastric biopsies commonly showed a full\u2010thickness active chronic gastritis with surface epithelial injury involving the antrum and body. Glandular atrophy, intra\u2010epithelial lymphocytosis and\/or subepithelial collagen thickening were also present in some cases. Duodenal involvement, including villous atrophy, intra\u2010epithelial lymphocytosis and\/or collagenous sprue, was identified in 11 of 13 cases with concurrent duodenal biopsies. Following drug cessation, symptomatic improvement occurred in all 11 cases for which follow\u2010up data were available. Histological resolution occurred in five of eight cases with follow\u2010up gastric biopsies, with improvement seen in the remaining three biopsies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ARB\u2010induced gastritis typically presents as active chronic gastritis, frequently with associated surface epithelial injury. Glandular atrophy, intra\u2010epithelial lymphocytosis and\/or subepithelial collagen thickening may also be present. These gastric changes can be seen without associated duodenal injury in rare cases, and they should alert the pathologist to the possibility of ARB\u2010induced injury. Drug cessation results in marked symptomatic and histological improvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14766","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T23:44:55Z","timestamp":1660088695000},"page":"653-660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The histological spectrum of\n                    <scp>ARB\u2010induced<\/scp>\n                    gastritis"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-9236","authenticated-orcid":false,"given":"Tanner","family":"Storozuk","sequence":"first","affiliation":[{"name":"University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-2547","authenticated-orcid":false,"given":"Ian","family":"Brown","sequence":"additional","affiliation":[{"name":"Envoi Pathology  Kelvin Grove QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Lagana","sequence":"additional","affiliation":[{"name":"Columbia University  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Westerhoff","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6060-4717","authenticated-orcid":false,"given":"Namrata","family":"Setia","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hart","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3599-8830","authenticated-orcid":false,"given":"Lindsay","family":"Alpert","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goz019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.06.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12780"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201410002-00875"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-226133"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0204-RA"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.07.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-12-4-230"},{"key":"e_1_2_7_10_1","first-page":"47","article-title":"Olmesartan and drug\u2010induced enteropathy","volume":"39","author":"Tran TH","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12937"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.12.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2013.12.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2017.15.3.419"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/his.14766","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T18:55:26Z","timestamp":1692644126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,23]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/his.14766"],"URL":"https:\/\/doi.org\/10.1111\/his.14766","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742454656.793597154","asserted-by":"object"}]},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,23]]},"assertion":[{"value":"2022-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}