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Tailgut cyst is the most common cyst of developmental origin, usually presenting as a multilocular cystic mass with mucoid content and lined by multiple epithelial types. Compared with tailgut cysts, rectal duplication cysts display all layers of the large bowel wall including a well\u2010defined muscularis propria. Retrorectal cysts of non\u2010developmental origin are far less common and represent lesions that either infrequently involve the retrorectal space or undergo extensive cystic change. This review provides an overview of the various histological types of cystic lesions of the retrorectal space, divided into cysts of developmental origin and those of non\u2010developmental origin. A practical pathological and multidisciplinary approach to diagnosing these lesions is presented.<\/jats:p>","DOI":"10.1111\/his.14769","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T09:09:12Z","timestamp":1660381752000},"page":"232-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cystic lesions of the retrorectal space"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-2547","authenticated-orcid":false,"given":"Ian S","family":"Brown","sequence":"first","affiliation":[{"name":"Envoi Specialist Pathologists  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-6181","authenticated-orcid":false,"given":"Anna","family":"Sokolova","sequence":"additional","affiliation":[{"name":"Sullivan Nicolaides Pathology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-2651","authenticated-orcid":false,"given":"Christophe","family":"Rosty","sequence":"additional","affiliation":[{"name":"Envoi Specialist Pathologists  Brisbane Queensland Australia"},{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rondell P","family":"Graham","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1285999"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0122-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.17329"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481007600108"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480907501113"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553440"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3501-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001520108"},{"key":"e_1_2_8_10_1","first-page":"69","article-title":"The developing human\u2010e\u2010book: clinically oriented embryology","volume":"1","author":"Moore KL","year":"2018","journal-title":"Elsevier Health Sci."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/aja.aja_72_19"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0725-RCH"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/89.2.139"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14628"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.16030"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3393\/ac.2018.12.18"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12919"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.5.01841519"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2018.11.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.4.310"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.919803"},{"key":"e_1_2_8_22_1","volume-title":"Tailgut cyst (retrorectal cystic hamartoma): a pathological review of 70 cases. 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