{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:31:46Z","timestamp":1791498706004,"version":"4.3.4"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005676","name":"Fundaci\u00f3n Josep Carreras Contra la Leucemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005676","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/01588"],"award-info":[{"award-number":["PI19\/01588"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"The frequency of aggressive subtypes of B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL), such as high\u2010grade B\u2010cell lymphomas (HGBL) with MYC<\/jats:italic> and BCL2<\/jats:italic> and\/or BCL6<\/jats:italic> rearrangement (HGBL\u2010DH\/TH) or Burkitt\u2010like lymphoma (BL) with 11q aberration, is not well known in the HIV setting. We aimed to characterise HIV\u2010associated aggressive B\u2010NHL according to the 2017 WHO criteria, and to identify genotypic and phenotypic features with prognostic impact. Seventy\u2010five HIV\u2010associated aggressive B\u2010NHL were studied by immunohistochemistry (CD10, BCL2, BCL6, MUM1, MYC, and CD30), EBV\u2010encoded RNAs (EBERs), and fluorescence in\u2009situ<\/jats:italic> hybridisation (FISH) to evaluate the status of the MYC<\/jats:italic>, BCL2<\/jats:italic>, and BCL6<\/jats:italic> genes and chromosome 11q. The 2017 WHO classification criteria and the Hans algorithm, for the cell\u2010of\u2010origin classification of diffuse large B\u2010cell lymphomas (DLBCL), were applied. In DLBCL cases, the frequencies of MYC<\/jats:italic> and BCL6<\/jats:italic> rearrangements (14.9 and 27.7%, respectively) were similar to those described in HIV\u2010negative patients, but BCL2<\/jats:italic> rearrangements were infrequent (4.3%). MYC expression was identified in 23.4% of DLBCL cases, and coexpression of MYC and BCL2 in 13.0%, which was associated with a worse prognosis. As for BL cases, the expression of MUM1 (30.4%) conferred a worse prognosis. Finally, the prevalence of HGBL\u2010DH\/TH and BL\u2010like with 11q aberration are reported in the HIV setting. The phenotypic and genotypic characteristics of HIV\u2010associated aggressive B\u2010NHL are similar to those of the general population, except for the low frequency of BCL2<\/jats:italic> rearrangements in DLBCL. MYC and BCL2 coexpression in DLBCL, and MUM\u20101 expression in BL, have a negative prognostic impact on HIV\u2010infected individuals.<\/jats:p>","DOI":"10.1111\/his.14798","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T01:23:32Z","timestamp":1663291412000},"page":"826-840","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetic and phenotypic characterisation of HIV<\/scp>\u2010associated aggressive B\u2010cell non\u2010Hodgkin<\/scp> lymphomas, which do not occur specifically in this population: diagnostic and prognostic implications"],"prefix":"10.1111","volume":"81","author":[{"given":"Maria Joao","family":"Baptista","sequence":"first","affiliation":[{"name":"Department of Hematology, ICO\u2010Germans Trias i Pujol Hospital, Josep Carreras Leukaemia Research Institute (IJC) Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Tapia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Germans Trias i Pujol, IGTP Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u2010Mar\u00eda","family":"Mu\u00f1oz\u2010Marmol","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Germans Trias i Pujol, IGTP Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Muncunill","sequence":"additional","affiliation":[{"name":"Department of Hematology, ICO\u2010Germans Trias i Pujol Hospital, Josep Carreras Leukaemia Research Institute (IJC) Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Hematology, ICO\u2010Germans Trias i Pujol Hospital, Josep Carreras Leukaemia Research Institute (IJC) Universitat Aut\u00f2noma de Barcelona Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"Centre for Haemato\u2010Oncology Barts Cancer Institute, Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G","family":"Gribben","sequence":"additional","affiliation":[{"name":"Centre for Haemato\u2010Oncology Barts Cancer Institute, Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Calaminici","sequence":"additional","affiliation":[{"name":"Centre for Haemato\u2010Oncology Barts Cancer Institute, Queen Mary University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Clinic, IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Veloza","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Clinic, IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Mart\u00ednez\u2010Trillos","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Clinic, IDIBAPS University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Aldamiz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Menarguez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Jos\u00e9","family":"Terol","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Hospital Cl\u00ednic Universitari de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ferrandez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Cl\u00ednic Universitari de Val\u00e8ncia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Alcoceba","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital Universitario de Salamanca (HUS\/IBSAL), CIBERONC and Centro de Investigaci\u00f3n del C\u00e1ncer\u2010IBMCC 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