{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T03:04:47Z","timestamp":1769828687654,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>The introduction of bowel cancer population screening programs has had a profound impact on gastrointestinal pathology. While the focus is mainly on quality assurance of diagnoses relevant for the outcome of these programs (colorectal cancer and its precursors), incidental findings are increasingly diagnosed. The incidence of such findings is largely unknown. Therefore, we investigated the incidence of incidental findings within the national screening program of the Netherlands. From the Dutch nationwide pathology databank (PALGA), we retrieved all histological diagnoses of patients participating in the national bowel cancer screening program from the start in 2014 until 1\/1\/2021. Descriptive statistics were used. During these 7\u2009years, in total 9407 other polyps and malignancies (262 per 10,000 colonoscopies) were diagnosed. The majority (65%) were classified as inflammatory polyps. The most common malignancies were neuroendocrine tumours (<jats:italic>n<\/jats:italic>\u2009=\u2009198, 6 per 10,000 colonoscopies); less common were lymphomas (<jats:italic>n<\/jats:italic>\u2009=\u200964) and metastases (<jats:italic>n<\/jats:italic>\u2009=\u200933). Mesenchymal polyps, such as leiomyomas and lipomas, were relatively common (27 and 16 per 10,000 colonoscopies, respectively), in comparison with neural polyps such as perineuriomas, ganglioneuromas, and neurofibromas (respectively 3, 2, and 1 per 10,000 colonoscopies). This is the largest study into the incidence of nonconventional colorectal polyps and malignancies in a homogeneous cohort of asymptomatic patients. Several of these diagnoses may have consequences for treatment and follow\u2010up, in particular the malignancies and detection of patients with hereditary cancer syndromes.<\/jats:p>","DOI":"10.1111\/his.14805","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T12:35:18Z","timestamp":1664195718000},"page":"254-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Incidental findings in the bowel cancer population screening program: other polyps and malignancies \u2013 A nationwide study"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0887-4127","authenticated-orcid":false,"given":"Iris D","family":"Nagtegaal","sequence":"first","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Vink\u2010B\u00f6rger","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboudumc  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal C H J","family":"Kuijpers","sequence":"additional","affiliation":[{"name":"PALGA foundation  Houten the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelien","family":"Dekker","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-6580","authenticated-orcid":false,"given":"Neil A","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Gloucestershire Cellular Pathology Laboratory Cheltenham General Hospital  Cheltenham UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13834"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13155"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13092"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.066"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12530"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/gidisord1020021"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300843"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327296"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1988.tb02093.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652407779940404"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt277"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.11.022"},{"key":"e_1_2_8_14_1","first-page":"19","article-title":"Pathology databanking and biobanking in The Netherlands, a central role for PALGA, the nationwide histopathology and cytopathology data network and archive","volume":"29","author":"Casparie M","year":"2007","journal-title":"Cell. 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