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Their morphologic overlap with non\u2010mesenchymal lesions (such as metaplastic carcinoma and phyllodes tumour) and relative rarity also pose significant diagnostic challenges. In this review, we summarize the salient features of selected mesenchymal lesions of the breast, emphasizing those that are the most common and problematic. Vascular, fibroblastic\/myofibroblastic, adipocytic, and smooth muscle lesions are each covered with regard to their clinicopathological features and differential diagnosis, while recent advances and the role of immunohistochemistry and molecular tests are also highlighted.<\/jats:p>","DOI":"10.1111\/his.14810","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:13:19Z","timestamp":1670544799000},"page":"83-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mesenchymal lesions of the breast"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-7831","authenticated-orcid":false,"given":"William J","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-9537","authenticated-orcid":false,"given":"Christopher D M","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02794.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001517"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.141"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2170::AID-CNCR11>3.0.CO;2-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0555-RS"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000184809.27735.a1"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080475"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198707000-00001"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000540"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31825d532d"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.164"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00844-4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/25.3.241"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03162-x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.118"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-95"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22663"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80292-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199503000-00004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00834-6"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000668"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910385679"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4865"},{"key":"e_1_2_5_25_1","volume-title":"World Health Organisation classification of soft tissue and bone tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3180581fff"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000170343.09562.39"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12898"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12567"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-197904000-00006"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/68.1.21"},{"key":"e_1_2_5_32_1","first-page":"308","article-title":"Incidence of perilobular hemangioma in the female breast","volume":"107","author":"Lesueur GC","year":"1983","journal-title":"Arch. 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