{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:35:56Z","timestamp":1792157756299,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>Squamous cell carcinoma (SCC) is the most common malignant tumour of the penis. The 2022 WHO classification reinforces the 2016 classification and subclassifies precursor lesions and tumours into human papillomavirus (HPV)\u2010associated and HPV\u2010independent types.<\/jats:p>\n                  <jats:p>HPV\u2010associated penile intraepithelial neoplasia (PeIN) is a precursor lesion of invasive HPV\u2010 associated SCC, whereas differentiated PeIN is a precursor lesion of HPV\u2010independent SCC. Block\u2010type positivity of p16 immunohistochemistry is the most practical daily utilised method to separate HPVassociated from HPVindependent penile SCC. If this is not feasible, the term SCC, not otherwise specified (NOS) is appropriate. Certain histologies that were previously classified as\u00a0\u201csubtypes\u201d are now grouped, and coalesced as \u201cpatterns\u201d, under the rubric of usual type SCC and verrucous carcinoma (e.g. usual\u2010type SCC includes pseudohyperplastic and acantholytic\/pseudoglandular carcinoma, and carcinoma cuniculatum is included as a pattern of verrucous carcinoma). If there is an additional component of the usual type of invasive SCC (formerly termed hybrid histology), the tumour would be a mixed carcinoma (e.g. carcinoma cuniculatum or verrucous carcinoma with usual invasive SCC); in such cases, reporting of the relative percentages in mixed tumours may be useful. The consistent use of uniform nomenclature and reporting of percentages will inform the refinement of future reporting classification schemes and guidelines\/recommendations.<\/jats:p>\n                  <jats:p>The classification of scrotal tumours is provided for the first time in the fifth edition of the WHO Blue book, and it follows the schema of penile cancer classification for both precursor lesions and the common SCC of the scrotum. Basal cell carcinoma of the scrotum may have a variable clinical course and finds a separate mention.<\/jats:p>","DOI":"10.1111\/his.14824","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T02:26:32Z","timestamp":1665541592000},"page":"508-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["WHO 2022 classification of penile and scrotal cancers: updates and evolution"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-0671","authenticated-orcid":false,"given":"S","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Pathology Tata Memorial Centre, Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Moch","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital Zurich  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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Tsuzuki","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Aichi Medical University  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-543X","authenticated-orcid":false,"given":"E","family":"Comp\u00e9rat","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna, General Hospital of Vienna  Wien AT Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universitat Erlangen\u2010Nurnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Netto","sequence":"additional","affiliation":[{"name":"Heersink School of Medicine The University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MA","family":"Rubin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research (DBMR) Bern Center for Precision Medicine Inselspital University Hospital Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AJ","family":"Gill","sequence":"additional","affiliation":[{"name":"Sydney Medical School Sydney The University of Sydney  NSW Australia"},{"name":"Royal North Shore Hospital, NSW Health Pathology Department of Anatomical Pathology St Leonards  NSW Australia"},{"name":"Royal North Shore Hospital, Pathology Group Kolling Institute of Medical Research  St Leonards NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Turajlic","sequence":"additional","affiliation":[{"name":"The Francis Crick Institute London and The Royal Marsden NHS Foundation Trust  London 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