{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:06:14Z","timestamp":1787169974331,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                    The aim of this study was to investigate the role of immunohistochemical (IHC) expression of p53 and other potential clinical parameters as prognostic markers for predicting neoplastic progression in Barrett oesophagus (BE) patients diagnosed as indefinite for dysplasia (IND). The study included patients with established BE of any extent who had a diagnosis of IND accompanied by concurrent p53 immunohistochemistry (IHC) stain at the index endoscopic procedure and at least one follow\u2010up examination between 2000 and 2021. Correlation between disease progression from IND to higher\u2010grade dysplasia [low\u2010grade dysplasia (LGD), high\u2010grade dysplasia (HGD) and oesophageal adenocarcinoma (EAC)] and clinicopathological parameters were analysed. A total of 149 patients (99 males; mean age 63.3\u2009\u00b1\u200910.0\u2009years, range\u00a0=\u00a035\u201389) were included in the final analysis. Median follow\u2010up was 37.1\u2009months [interquartile range (IQR)\u00a0=\u00a020.5\u201359.1\u2009months]. Progression rates from IND to LGD and HGD were 12.1% (18 of 149) and 2.7% (four of 149), respectively. On multivariate analysis, the number of IND diagnoses was significantly associated with progression to both LGD and HGD (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.016 and\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u20090.001, respectively). Cox regression analysis showed that aberrant p53 expression was significantly associated with progression to LGD [hazard ratio (HR)\u00a0=\u00a04.87, 95% confidence interval (CI)\u00a0=\u00a01.91\u201312.45,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.001] and HGD (HR\u00a0=\u00a021.81, 95% CI\u00a0=\u00a01.88\u2013253.70,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.014). Kaplan\u2013Meier survival analysis also demonstrated that aberrant p53 expression was significantly associated with progression to LGD (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u20090.001) and HGD (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u20090.001). Our results suggest that frequency of IND diagnoses and status of p53 expression can help to stratify risk of neoplastic progression in BE patients with IND.\n                  <\/jats:p>","DOI":"10.1111\/his.14828","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:49:26Z","timestamp":1666010966000},"page":"454-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aberrant p53 expression is associated with neoplastic progression in Barrett oesophagus diagnosed as indefinite for dysplasia"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-7012","authenticated-orcid":false,"given":"Xiuxu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-3922","authenticated-orcid":false,"given":"Bella Lingjia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-2200","authenticated-orcid":false,"given":"Noam","family":"Harpaz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfa","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8604-0756","authenticated-orcid":false,"given":"Alexandros D.","family":"Polydorides","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Molecular &amp; Cell\u2010Based Medicine, Icahn School of Medicine at Mount Sinai  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0012"},{"key":"e_1_2_8_4_1","unstructured":"HowladerN.SEER Cancer Statistics Review (CSR) 1975\u20132017NIH National Cancer Institute Bethesda MD;2020[updated April 15 2020.https:\/\/seer.cancer.gov\/archive\/csr\/1975_2017\/:Based on November 2019 SEER data submission posted to the SEER web site]."},{"issue":"12","key":"e_1_2_8_5_1","first-page":"e3709","article-title":"Incidence of esophageal cancer in the United States from 2001\u20102015: a United States cancer statistics analysis of 50 states","volume":"10","author":"Patel N","year":"2018","journal-title":"Cureus"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198608073150605"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13134"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90057-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035337"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80344-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000062996.66432.12"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.251"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.07.037"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.23511"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4292\/wjgpt.v7.i3.406"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03571.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ctg.2015.7"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12696"},{"issue":"5","key":"e_1_2_8_19_1","first-page":"409","article-title":"Risk of neoplastic progression in Barrett's esophagus diagnosed as indefinite for dysplasia: a nationwide cohort study","volume":"47","author":"Kestens C","year":"2015","journal-title":"Endoscopy"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12956"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303594"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03851.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00313029800169076"},{"issue":"10","key":"e_1_2_8_24_1","first-page":"1005","article-title":"Diagnostic significance of nuclear p53 expression in the surveillance of Barrett's esophagus\u2010\u2010a longitudinal study","volume":"37","author":"Klump B","year":"1999","journal-title":"Z. 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