{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:13:34Z","timestamp":1780611214847,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY21H160052"],"award-info":[{"award-number":["LY21H160052"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p><jats:italic>RET<\/jats:italic>\u2010fused mesenchymal neoplasms mostly affect the soft tissue of paediatric patients. Given their responsiveness to selective <jats:italic>RET<\/jats:italic> inhibitors, it remains critical to identify those extraordinary cases occurring in the visceral organs of adults. In this study, we report three <jats:italic>RET<\/jats:italic>\u2010rearranged spindle\u2010cell tumours occurring in the visceral organs of adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Clinicopathological features were assessed and partner agnostic targeted next\u2010generation sequencing on clinically validated platforms were performed. The patients were 18, 53, and 55\u2009years old and included one male and two females. The tumours were located in the kidney (case 1), small intestine (case 2), and ureter (case 3), with maximum diameters of 14, 5, and 1\u00a0cm, respectively. Histologically, all tumours displayed a morphological spectrum typical of fibrosarcoma, including moderately to highly cellular, nonpleomorphic, ovoid to spindle\u2010shaped cells arranged in long fascicles or haphazardly within collagenised to myxohyaline stroma. Foci of irregular alveolar oedema\u2010like structures and areas with microcystic and reticular arrangements were identified in the renal tumour. Staghorn\u2010type vessels and foci of band\u2010like stromal hyalinisation were observed in the small intestine tumour. Cases 1 and 2 were high\u2010grade and pursed a highly aggressive clinical course, while case 3 was of intermediate grade with no tumour recurrence or metastasis 14\u2009years after surgery. All three tumours expressed CD34, which was coexpressed with S100 protein in cases 2 and 3. Molecular genetic testing revealed <jats:italic>PRKAR1A::RET<\/jats:italic>, <jats:italic>KIF5B::RET<\/jats:italic>, and <jats:italic>SPECC1L::RET<\/jats:italic> in\u2010frame gene fusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study expands the clinicopathological and genetic spectrum of mesenchymal neoplasms associated with <jats:italic>RET<\/jats:italic> fusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14847","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T07:45:14Z","timestamp":1669707914000},"page":"633-645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Recurrent <i>RET<\/i> fusions in fibrosarcoma\u2010like neoplasms in\u00a0adult viscera: expanding the clinicopathological and genetic spectrum"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5971-7303","authenticated-orcid":false,"given":"Ming","family":"Zhao","sequence":"first","affiliation":[{"name":"Cancer Center, Department of Pathology Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pathology Hangzhou Women's Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-2190","authenticated-orcid":false,"given":"Huiying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center  Beijing 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