{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:13:36Z","timestamp":1780089216952,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070207"],"award-info":[{"award-number":["82070207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["21ZR1440100"],"award-info":[{"award-number":["21ZR1440100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Indolent natural killer (NK) cell lymphoproliferative disorder of the gastrointestinal (GI) tract (iNKLPD) is a rare, recently recognised neoplasm. Most of the reported tumours are confined to the GI tract, while a small subset of the tumours harbour JAK3 mutations. We collected four cases of iNKLPD with the goal of adding additional information to the current knowledge of this disease regarding the clinicopathological, immunohistochemical and molecular features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Similar features including medium\u2010 to large\u2010sized lymphoid cells with variable amounts of pale or slightly eosinophilic cytoplasm, and no evidence of EBER, TCR rearrangement were found in four cases. JAK3 K563_C565del mutation was found in one of three cases that were subjected to targeted next\u2010generation sequencing. Unique findings of our study include one iNKLPD encountered for the first time in nasopharynx, where lesions could be inadvertently diagnosed as extranodal NK\/T cell lymphoma, and one iNKLPD located in the gallbladder extended deeply into muscular and adventitial layers. Exceptional CD8\u2010positive expression was observed in one iNKLPD. In addition, positive staining of phospho\u2010STAT5, phospho\u2010STAT3 and phospho\u2010p38 were found in our cases. None of the four patients received therapy for lymphoma, but all had a benign clinical outcome during a follow\u2010up time of 20\u201399\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We present four iNKLPDs with clinical, immunohistochemical and molecular features similar to the reported cases, as well as some unusual characters, which expand our knowledge on this disease, and further support the neoplastic nature of iNKLPDs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14850","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T04:14:11Z","timestamp":1670645651000},"page":"567-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinicopathological and molecular features of indolent natural killer\u2010cell lymphoproliferative disorder of the gastrointestinal tract"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2054-6401","authenticated-orcid":false,"given":"Hongmei","family":"Yi","sequence":"first","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binshen","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Da","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  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Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Xinjiang Medical University  Xinjiang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pathology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University  Zhejiang"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Ruijin Hospital, Shanghai Jiaotong University School of Medicine  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