{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:21:03Z","timestamp":1778520063779,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007278","name":"Henry Ford Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Renal cell carcinoma (RCC) with clear cells and psammoma\u2010like calcifications would often raise suspicion for MITF family translocation RCC. However, we have rarely encountered tumours consistent with clear cell RCC that contain focal psammomatous calcifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We identified clear cell RCCs with psammomatous calcifications from multiple institutions and performed immunohistochemistry and fluorescence and RNA <jats:italic>in\u2010situ<\/jats:italic> hybridisation (FISH and RNA ISH). Twenty\u2010one tumours were identified: 12 men, nine women, aged 45\u201383\u2009years. Tumour size was 2.3\u201314.0\u2009cm (median\u00a0=\u00a06.75\u2009cm). Nucleolar grade was 3 (<jats:italic>n<\/jats:italic>\u00a0=\u200914), 2 (<jats:italic>n<\/jats:italic>\u00a0=\u20094) or 4 (<jats:italic>n<\/jats:italic>\u00a0=\u20093). In addition to clear cell pattern, morphology included eosinophilic (<jats:italic>n<\/jats:italic>\u00a0=\u200912), syncytial giant cell (<jats:italic>n<\/jats:italic>\u00a0=\u20094), rhabdoid (<jats:italic>n<\/jats:italic>\u00a0=\u20092), branched glandular (<jats:italic>n<\/jats:italic>\u00a0=\u20091), early spindle cell (<jats:italic>n<\/jats:italic>\u00a0=\u20091) and poorly differentiated components (<jats:italic>n<\/jats:italic>\u00a0=\u20091). Labelling for CA9 was usually 80\u2013100% of the tumour cells (<jats:italic>n<\/jats:italic>\u00a0=\u200917 of 21), but was sometimes decreased in areas of eosinophilic cells (<jats:italic>n<\/jats:italic>\u00a0=\u20094). All (19 of 19) were positive for CD10. Most (19 of 20) were positive for AMACR (variable staining\u00a0=\u00a020\u2013100%). Staining was negative for keratin 7, although four showed rare positive cells (four of 20). Results were negative for cathepsin K (none of 19), melan A (none of 17), HMB45 (none of 17), TFE3 (none of 5), TRIM63 RNA ISH (none of 13), and <jats:italic>TFE3<\/jats:italic> (none of 19) and <jats:italic>TFEB<\/jats:italic> rearrangements (none of 12). Seven of 19 (37%) showed chromosome 3p deletion. One (one of 19) showed trisomy 7 and 17 without papillary features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psammomatous calcifications in RCC with a clear cell pattern suggests a diagnosis of MITF family translocation RCC; however, psammomatous calcifications can rarely be found in true clear cell RCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14854","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T07:15:30Z","timestamp":1671866130000},"page":"684-690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clear cell renal cell carcinoma with focal psammomatous calcifications: a rare occurrence mimicking translocation carcinoma"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-8964","authenticated-orcid":false,"given":"Ankur R","family":"Sangoi","sequence":"first","affiliation":[{"name":"El Camino Hospital  Mountain View CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8751","authenticated-orcid":false,"given":"Khaleel I","family":"Al\u2010Obaidy","sequence":"additional","affiliation":[{"name":"Henry Ford Health System  Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Brown University Warren Albert Medical School  Providence RI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Sui","family":"Kao","sequence":"additional","affiliation":[{"name":"Stanford Medicine\/Stanford University  Stanford CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7290-4004","authenticated-orcid":false,"given":"Emily","family":"Chan","sequence":"additional","affiliation":[{"name":"University of California  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudha","family":"Sadasivan","sequence":"additional","affiliation":[{"name":"Mexican Oncology Hospital SXXI, IMSS  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert M","family":"Levin","sequence":"additional","affiliation":[{"name":"Mexican Oncology Hospital SXXI, IMSS  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Alvarado\u2010Cabrero","sequence":"additional","affiliation":[{"name":"Mexican Oncology Hospital SXXI, IMSS  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi P","family":"Kunju","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-8884","authenticated-orcid":false,"given":"Rohit","family":"Mehra","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Mannan","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xioming","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasreman","family":"Dhillon","sequence":"additional","affiliation":[{"name":"H. 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