{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:08:00Z","timestamp":1791338880867,"version":"4.3.1"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T00:00:00Z","timestamp":1677974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["724281"],"award-info":[{"award-number":["724281"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["11618\/2018"],"award-info":[{"award-number":["11618\/2018"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["12949\/2020"],"award-info":[{"award-number":["12949\/2020"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Large B cell lymphoma with <jats:italic>IRF4<\/jats:italic> rearrangement (LBCL\u2010IRF4) is a new entity in the 2017 revised World Health Organisation (WHO) classification that was initially mainly reported in children. After identification of a 79\u2010year\u2010old patient, we assessed how often <jats:italic>IRF4<\/jats:italic> rearrangements can be detected in adult diffuse large B cell lymphomas (DLBCLs) which have to be reclassified to LBCL\u2010IRF4 based on fluorescence in\u2010situ hybridisation (FISH) for <jats:italic>IRF4<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>With FISH, we studied the presence of <jats:italic>IRF4<\/jats:italic> rearrangements in 238 lymphomas that were diagnosed as DLBCL according to the previous WHO classification of 2008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to the index patient, an <jats:italic>IRF4<\/jats:italic> rearrangement was detected in another five of 237 patients (2%). The immunohistochemical profile of these five <jats:italic>IRF4<\/jats:italic> rearranged lymphomas was consistent with previous reports of LBCL\u2010IRF4. One case was recognised to represent transformation of follicular lymphoma rather than de\u2010novo LBCL\u2010IRF4. BCL6 rearrangements were found in two cases of LBCL\u2010IRF4; <jats:italic>BCL2<\/jats:italic> and <jats:italic>MYC<\/jats:italic> rearrangements were excluded. Patients presented with limited stage disease with involvement of the head and neck in three patients, and involvement of the lung and thyroid in two others. This study shows that, although rare, LBCL\u2010IRF4 should also be considered in older patients and\u00a0at localisations other than the head and neck region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14885","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T08:21:37Z","timestamp":1676276497000},"page":"1013-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reclassification of diffuse large B cell lymphoma to large B cell lymphoma with <i>IRF4<\/i> rearrangement in an adult population"],"prefix":"10.1111","volume":"82","author":[{"given":"Eva A M","family":"Hesius","sequence":"first","affiliation":[{"name":"Department of Hematology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"van Laar","sequence":"additional","affiliation":[{"name":"Pathology\u2010DNA Rijnstate Hospital  Arnhem the Netherlands"},{"name":"Pathology\u2010DNA, St Antonius Hospital  Nieuwegein the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet","family":"Oosterveld","sequence":"additional","affiliation":[{"name":"Department of Hematology Canisius\u2010Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek B","family":"van Spriel","sequence":"additional","affiliation":[{"name":"Department of Tumor Immunology Radboud Institute for Molecular Life Sciences, Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Scheijen","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Leeuwis","sequence":"additional","affiliation":[{"name":"Pathology\u2010DNA Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri A M","family":"Marres","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J T A","family":"Groenen","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy B C","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Hematology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"van der Spek","sequence":"additional","affiliation":[{"name":"Department of Hematology Rijnstate Hospital  Arnhem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriaan J C","family":"van den Brule","sequence":"additional","affiliation":[{"name":"Pathology\u2010DNA Jeroen Bosch Hospital  Den Bosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigiet M","family":"Hoevenaars","sequence":"additional","affiliation":[{"name":"Department of Pathology Canisius\u2010Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konnie M","family":"Hebeda","sequence":"additional","affiliation":[{"name":"Department of Pathology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-6254","authenticated-orcid":false,"given":"Michiel","family":"van den Brand","sequence":"additional","affiliation":[{"name":"Pathology\u2010DNA Rijnstate Hospital  Arnhem the Netherlands"},{"name":"Department of Pathology Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-022-00968-0"},{"key":"e_1_2_11_4_1","unstructured":"SwerdlowSH CE HarrisNLet al.WHO classification of tumours of haematopoietic and lymphoid tissues revised 4th editon 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