{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:37:27Z","timestamp":1785195447625,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972171"],"award-info":[{"award-number":["81972171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472173"],"award-info":[{"award-number":["81472173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Herein we describe a series of rare peripheral pulmonary neoplasms temporarily termed \u201cperipheral type squamous cell neoplasm of uncertain malignant potential (PSCN\u2010UMP)\u201d and investigate their relationship to bronchiolar adenoma (BA) and squamous cell carcinoma (SCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The histologic and immunohistochemical features of 10 PSCN\u2010UMPs and six BAs were compared. Whole exome sequencing (WES) and bioinformatics analysis were performed to further compare the genetic features of PSCN\u2010UMPs, BAs, and NSCLCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All PSCN\u2010UMPs were peripherally located and histologically characterised by the lepidic, nested, and papillary proliferation of relatively bland squamous cells, accompanied by entrapped hyperplastic reactive pneumocytes. The basal squamous cells coexpressed TTF1 and squamous markers. Both cellular components exhibited bland morphology and a low proliferative activity. The six BAs met the morphologic and immunophenotypic features of proximal\u2010type BA. Genetically, driver mutations, including frequent <jats:italic>EGFR<\/jats:italic> exon 20 insertions, were found in PSCN\u2010UMPs, while the <jats:italic>KRAS<\/jats:italic> mutation, <jats:italic>BRAF<\/jats:italic> mutation, and <jats:italic>ERC1::RET<\/jats:italic> fusion were detected in BAs. PSCN\u2010UMPs also shared some alterations with BAs in mutational signatures, while copy number variants (CNV) were enriched in <jats:italic>MET<\/jats:italic> and <jats:italic>NKX2\u20101<\/jats:italic> in PSCN\u2010UMP and <jats:italic>MCL1<\/jats:italic>, <jats:italic>MECOM<\/jats:italic>, <jats:italic>SGK1<\/jats:italic>, and <jats:italic>PRKAR1A<\/jats:italic> in BA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PSCN\u2010UMPs exhibited the proliferation of bland squamous cells accompanied by entrapped pneumocytes and frequent <jats:italic>EGFR<\/jats:italic> exon 20 insertions, which showed distinct features from BAs and SCCs. Recognition of this specific entity will help to expand the morphologic and molecular spectrum of peripheral lung squamous neoplasms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14890","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T18:46:36Z","timestamp":1676745996000},"page":"178-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Frequent <i>EGFR<\/i> exon 20 insertion in the so\u2010called peripheral\u2010type squamous cell neoplasm of uncertain malignant potential: a variant of bronchiolar adenoma or under\u2010recognised entity?"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-8918","authenticated-orcid":false,"given":"Qiang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Fudan University Shanghai 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