{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:26:00Z","timestamp":1790886360527,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:00:00Z","timestamp":1680220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To report novel observations in five mesonephric\u2010like adenocarcinomas (MLAs) of the female genital tract.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      We report two endometrial MLAs in association with endometrioid carcinoma and atypical hyperplasia and three (one endometrial, two ovarian) cases with a sarcomatoid component (mesonephric\u2010like carcinosarcoma). Pathogenic\n                      <jats:italic>KRAS<\/jats:italic>\n                      mutations, which are characteristic of MLA, were identified in all cases although interestingly, in one of the mixed carcinomas, this was confined to the endometrioid component. The concurrent MLA, endometrioid carcinoma and atypical hyperplasia components in one case harboured identical\n                      <jats:italic>EGFR<\/jats:italic>\n                      ,\n                      <jats:italic>PTEN<\/jats:italic>\n                      and\n                      <jats:italic>CCNE1<\/jats:italic>\n                      mutations, suggesting that the atypical hyperplasia gave rise to a M\u00fcllerian carcinoma with both endometrioid and mesonephric\u2010like components. The carcinosarcomas all contained a component of MLA and a sarcomatous component with chondroid elements. In the ovarian carcinosarcomas, the coexisting epithelial and sarcomatous components shared some mutations including\n                      <jats:italic>KRAS<\/jats:italic>\n                      and\n                      <jats:italic>CREBBP<\/jats:italic>\n                      , suggesting that they are clonally related. Furthermore, in one case\n                      <jats:italic>CREBBP<\/jats:italic>\n                      and\n                      <jats:italic>KRAS<\/jats:italic>\n                      mutations detected in the MLA and sarcomatous components were also detected in an associated undifferentiated carcinoma component, suggesting that it was clonally related to the MLA and sarcomatous components.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our observations provide additional evidence that MLAs have a M\u00fcllerian origin and characterise mesonephric\u2010like carcinosarcomas in which chondroid elements appear to be characteristic. In reporting these findings, we provide recommendations for distinction between a mesonephric\u2010like carcinosarcoma and a MLA with a spindle cell component.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14892","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T01:55:51Z","timestamp":1677722151000},"page":"978-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Mesonephric\u2010like adenocarcinoma of the female genital tract: novel observations and detailed molecular characterisation of mixed tumours and mesonephric\u2010like carcinosarcomas"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4042-8389","authenticated-orcid":false,"given":"Jelena","family":"Mirkovic","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"},{"name":"Department of 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