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Limited data are available regarding the CD30 expression status of patients who relapsed after this therapy. This is the first study to show decreased CD30 expression in R\/R CHL in patients (<jats:italic>n<\/jats:italic>\u2009=\u20095) who underwent CAR T\u2010cell therapy in our institution between 2018 and 2022. Although conventional immunohistochemical assays showed decreased CD30 expression in neoplastic cells in all cases (8\/8) the tyramide amplification assay and RNAScope <jats:italic>in situ<\/jats:italic> hybridisation detected CD30 expression at different levels in 100% (<jats:italic>n<\/jats:italic>\u2009=\u20098\/8) and 75% (<jats:italic>n<\/jats:italic>\u2009=\u20093\/4), respectively. Hence, our findings document that certain levels of CD30 expression are retained by the neoplastic cells. This is not only of biological interest but also diagnostically important, as detection of CD30 is an essential factor in establishing a diagnosis of CHL.<\/jats:p>","DOI":"10.1111\/his.14910","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T15:50:29Z","timestamp":1680191429000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<scp>CD30<\/scp> expression is frequently decreased in relapsed classic Hodgkin lymphoma after <scp>anti\u2010CD30 CAR<\/scp> T\u2010cell therapy"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-2096","authenticated-orcid":false,"given":"Mario L.","family":"Marques\u2010Piubelli","sequence":"first","affiliation":[{"name":"Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematopathology The University of Texas MD Anderson Cancer Center  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-8006","authenticated-orcid":false,"given":"L. 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