{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:10:48Z","timestamp":1770531048385,"version":"3.49.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Nodal T follicular helper (TFH) cell lymphoma (nTFHL) is a rare type of clinically aggressive T cell lymphoma. With this lymphoma type, Epstein\u2013Barr virus (EBV) infection is frequently detected in non\u2010neoplastic B lymphocytes, but not yet identified in neoplastic T cells. We report two cases of nTFHL showing a classic morphology and immunoprofile, with EBV\u2010encoded small RNAs (EBER) <jats:italic>in\u2010situ<\/jats:italic> hybridisation positivity in neoplastic TFH cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Clonal T cell receptor (TR) gene rearrangement was detected in both cases. Whole exome sequencing identified <jats:italic>TET2<\/jats:italic>, <jats:italic>RHOA<\/jats:italic> p. G17V, as well as gene mutations unique to each case. Microdissection analysis showed EBER positivity in tumour cells and in background non\u2010neoplastic T lymphocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These two immunocompetent cases of nTFHL with EBV\u2010positive tumour cells exhibit the featured gene mutation profile and poor prognosis of this disease. This novel finding of EBV positivity in our cases expands the currently recognised spectrum of EBV\u2010positive nodal T cell lymphomas to include rare cases of nTFHL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14919","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T15:27:35Z","timestamp":1681831655000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A nodal EBV\u2010positive T cell lymphoma with a T follicular helper cell phenotype"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-3505","authenticated-orcid":false,"given":"Zhaoxuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2000-3255","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhouyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-7987","authenticated-orcid":false,"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"Intelligent Pathology Institute, Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui 230036 China"},{"name":"State Key Laboratory of Cancer Biology, Department of Pathology Xijing Hospital and School of Basic Medicine, Fourth Military Medical University  China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.158428"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-02-698977"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2019.12.005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-020-00188-w"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000555"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.01.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1768382"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1111708"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2872"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.02.005"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:05:19Z","timestamp":1693296319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,18]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/his.14919"],"URL":"https:\/\/doi.org\/10.1111\/his.14919","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,18]]},"assertion":[{"value":"2022-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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