{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:45:01Z","timestamp":1791229501509,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to the posterolateral sides of the prostate reduces the number of complications at the risk of positive surgical margins. Preoperative selection of men eligible for safe, nerve\u2010sparing surgery is therefore needed. Our aim was to identify pathological factors associated with positive posterolateral surgical margins in men undergoing bilateral nerve\u2010sparing RP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Prostate cancer patients undergoing RP with standardised intra\u2010operative surgical margin assessment according to the NeuroSAFE technique were included. Preoperative biopsies were reviewed for grade group (GG), cribriform and\/or intraductal carcinoma (CR\/IDC), perineural invasion (PNI), cumulative tumour length and extraprostatic extension (EPE). Of 624 included patients, 573 (91.8%) received NeuroSAFE bilaterally and 51 (8.2%) unilaterally, resulting in a total of 1197 intraoperative posterolateral surgical margin assessments. Side\u2010specific biopsy findings were correlated to ipsilateral NeuroSAFE outcome. Higher biopsy GG, CR\/IDC, PNI, EPE, number of positive biopsies and cumulative tumour length were all associated with positive posterolateral margins. In multivariable bivariate logistic regression, ipsilateral PNI [odds ratio (OR)\u2009=\u20092.98, 95% confidence interval (CI)\u2009= 1.62\u20135.48; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001] and percentage of positive cores (OR\u2009=\u20091.18, 95% CI\u2009=\u20091.08\u20131.29; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001)\u00a0were significant predictors for a positive posterolateral margin, while GG and CR\/IDC were not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ipsilateral PNI and percentage of positive cores were significant predictors for a positive posterolateral surgical margin at RP. Biopsy PNI and tumour volume can therefore support clinical decision\u2010making on the level of nerve\u2010sparing surgery in prostate cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14934","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T14:35:33Z","timestamp":1683210933000},"page":"348-356","source":"Crossref","is-referenced-by-count":8,"title":["Biopsy prostate cancer perineural invasion and tumour load are associated with positive posterolateral margins at radical prostatectomy: implications for planning of nerve\u2010sparing surgery"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7304-7542","authenticated-orcid":false,"given":"Margaretha A","family":"van der Slot","sequence":"first","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Pathology Maasstad Hospital  Rotterdam the Netherlands"},{"name":"Department of Urology Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9530-6448","authenticated-orcid":false,"given":"Sebastiaan","family":"Remmers","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Cancer Institute, University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-9612","authenticated-orcid":false,"given":"Charlotte F","family":"Kweldam","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Pathology Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8996-3134","authenticated-orcid":false,"given":"Michael A","family":"den Bakker","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Pathology Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Nieboer","sequence":"additional","affiliation":[{"name":"Department of Urology Erasmus MC Cancer Institute, University Medical Centre  Rotterdam the Netherlands"},{"name":"Department of Public Health Erasmus University Medical Center Rotterdam  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn B","family":"Busstra","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Urology Erasmus MC Cancer Institute, University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Gan","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Urology Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-2506","authenticated-orcid":false,"given":"Sjoerd","family":"Klaver","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Urology Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B W","family":"Rietbergen","sequence":"additional","affiliation":[{"name":"Anser Prostate Operation Clinic  Rotterdam the Netherlands"},{"name":"Department of Urology Franciscus Gasthuis and Vlietland  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2176-9102","authenticated-orcid":false,"given":"Geert J L H","family":"van Leenders","sequence":"additional","affiliation":[{"name":"Department of Pathology Erasmus MC Cancer Institute, University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Anser Prostate Cancer Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287218813787"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01351.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.10.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.12.037"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11315.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2019.1693625"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.03.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.09.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2019.08.016"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008-682X.173444"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.12.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.04.057"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2019.03.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15771"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14184"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000530"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v032.i10"},{"key":"e_1_2_8_19_1","unstructured":"BrownM.rmda: risk model decision analysis. R package version 16.CRAN 2018.https:\/\/cran.r-project.org\/web\/packages\/rmda\/rmda.pdf"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-77"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14078"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13573"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12763"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.08.008"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14026"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13733"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0319-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14395"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507268"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.03.021"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15938"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:27:36Z","timestamp":1691645256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/his.14934"],"URL":"https:\/\/doi.org\/10.1111\/his.14934","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]}}}