{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:37:53Z","timestamp":1791589073279,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Poroma is a benign adnexal neoplasm with differentiation towards the upper portion of the sweat gland apparatus. In 2019, Sekine <jats:italic>et\u00a0al.<\/jats:italic> demonstrated recurrent <jats:italic>YAP1::MAML2<\/jats:italic> and <jats:italic>YAP1::NUTM1<\/jats:italic> fusion in poroma and porocarcinoma. Follicular, sebaceous and\/or apocrine differentiation has been reported in rare cases of poroma and whether these tumours constitute a variant of poroma or represent a distinctive tumour is a matter to debate. Herein we describe the clinical, immunophenotypic, and molecular features of 13 cases of poroma with folliculo\u2010sebaceous differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Most of the tumours were located on the head and neck region (<jats:italic>n<\/jats:italic>\u2009=\u20097), and on the thigh (<jats:italic>n<\/jats:italic>\u2009=\u20093). All presented were adults with a slight male predilection. The median tumour size was 10\u2009mm (range: 4\u201325). Microscopically, lesions displayed features of poroma with nodules of monotonous basophilic cells associated with a second population of larger eosinophilic cells. In all cases, ducts and scattered sebocytes were identified. Infundibular cysts were present in 10 cases. In two cases high mitotic activity was noted, and in three cases cytologic atypia and areas of necrosis were identified. Whole transcriptome RNA sequencing demonstrated in\u2010frame fusion transcripts involving <jats:italic>RNF13::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20094), <jats:italic>EPHB3::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20092), <jats:italic>DLG1::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20092), <jats:italic>LRIG1::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091), <jats:italic>ATP1B3::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091), <jats:italic>TM9SF4::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091), and <jats:italic>CTNNA1::PAK2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u2009=\u20091). Moreover, fluorescence <jats:italic>in situ<\/jats:italic> hybridisation (FISH) analysis revealed <jats:italic>PAK2<\/jats:italic> rearrangement in an additional case. No <jats:italic>YAP1::MAML2<\/jats:italic> or <jats:italic>YAP1::NUTM1<\/jats:italic> fusion was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recurrent fusions involving the <jats:italic>PAK2<\/jats:italic> gene in all analysed poroma with folliculo\u2010sebaceous differentiation in this study confirms that this neoplasm represents a separate tumour entity distinct from <jats:italic>YAP1::MAML2<\/jats:italic> or <jats:italic>YAP1::NUTM1<\/jats:italic> rearranged poromas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14940","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:16:14Z","timestamp":1684419374000},"page":"310-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Recurrent <i>PAK2<\/i> rearrangements in poroma with folliculo\u2010sebaceous differentiation"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2201-6914","authenticated-orcid":false,"given":"Thibault","family":"Kervarrec","sequence":"first","affiliation":[{"name":"Department of Pathology Centre Hospitalier Universitaire de Tours, Universit\u00e9 de Tours  Tours France"},{"name":"\u201cBiologie des infections \u00e0 polyomavirus\u201d Team UMR INRA ISP 1282, Universit\u00e9 de Tours  Tours France"},{"name":"CARADERM Network  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-950X","authenticated-orcid":false,"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"},{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon, Equipe Labellis\u00e9e Ligue contre le Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Paindavoine","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Cancer Research Center of Lyon, Equipe Labellis\u00e9e Ligue contre le Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Osio","sequence":"additional","affiliation":[{"name":"Department of Pathology, APHP H\u00f4pital Saint Louis Universit\u00e9 Paris 7  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Mourah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Solid Tumor Genomics, Saint Louis Hospital Paris University AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan\u00e9lie","family":"Jouenne","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Solid Tumor Genomics, Saint Louis Hospital Paris University AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sohier","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Department of Pathology, H\u00f4pital Cochin AP\u2010HP.Centre\u2010Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Calonje","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, St John's Institute of Dermatology St Thomas's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Pekar","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, St John's Institute of Dermatology St Thomas's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Vanesa Erazo","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, St John's Institute of Dermatology St Thomas's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital  Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital  Sunto Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Dermatology Hyogo Cancer Center  Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flore","family":"Delalande","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Center of Orl\u00e9ans  Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Frouin","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Pathology University hospital of Poitiers  Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Macagno","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Pathology Timone University Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Drouot","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Pathology Cypath  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Faisan","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Pathology Cypath  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Cribier","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Dermatology Clinic H\u00f4pitaux Universitaires &amp; Universit\u00e9 de Strasbourg, H\u00f4pital Civil  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Pathology, APHP H\u00f4pital Saint Louis Universit\u00e9 Paris 7  Paris France"},{"name":"Department of Pathology APHP H\u00f4pital Saint Louis, INSERM U976, Universit\u00e9 Paris Cit\u00e9 7  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"de la Fouchardi\u00e8re","sequence":"additional","affiliation":[{"name":"CARADERM Network  Lille France"},{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030476"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200106000-00002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI126185"},{"key":"e_1_2_9_5_1","first-page":"59","article-title":"The infundibular adenoma: a follicular poroma with sebaceous and apocrine differentiation (author's transl)","volume":"108","author":"Grosshans E","year":"1981","journal-title":"Ann. Dermatol. 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