{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:34:24Z","timestamp":1792290864094,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Patients with non\u2010dysplastic Barrett's oesophagus (BE) often show a wide range of \u2018atypical\u2019 histological features in the bases of the crypts. However, the significance of crypt atypia has never been evaluated, despite prior studies showing the presence of DNA content and other molecular abnormalities in this epithelium. The aim of this study was to evaluate whether the degree of crypt atypia in BE patients without dysplasia correlates with progression to high\u2010grade dysplasia\/adenocarcinoma (HGD\/EAC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Baseline biopsies from 114 BE patients without dysplasia, 57 who progressed to HGD\/EAC (progressors) and 57 who did not progress (non\u2010progressors), were included in the study. Biopsies were evaluated for the degree of basal crypt atypia on a three\u2010point scale according to discrete histological criteria. In non\u2010progressors, 64.9, 31.6 and 3.5% of biopsies had a crypt atypia score of 1, 2 and 3, respectively, with a mean score of 1.39\u2009\u00b1\u20090.56. The percentage of biopsies with an atypia score of 2 or 3 increased in progressors [42.1,\u00a042.1 and 15.8% of biopsies scored 1, 2 or 3, respectively, with a mean score of 1.74\u2009\u00b1\u20090.72 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004)]. The odds ratio of grade 3 crypt atypia for progression to HGD\/EAC was 5.2 (95% confidence interval\u2009=\u20091.1\u201325.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) and the findings did not change significantly when the data were analysed according to progression to either HGD or EAC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study shows that non\u2010dysplastic crypts in BE are biologically abnormal, suggesting that neoplastic progression begins prior to the onset of dysplasia. The degree of crypt atypia in BE patients without dysplasia correlates with progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.14959","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T10:14:26Z","timestamp":1684404866000},"page":"406-413","source":"Crossref","is-referenced-by-count":5,"title":["Degree of crypt atypia correlates with progression to high\u2010grade dysplasia\/adenocarcinoma in non\u2010dysplastic Barrett's oesophagus"],"prefix":"10.1111","volume":"83","author":[{"given":"Robert","family":"Odze","sequence":"first","affiliation":[{"name":"Tufts University School of Medicine  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Frei","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Locatie AMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M","family":"Khoshiwal","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Locatie AMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas C","family":"Duits","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Locatie AMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Bergman","sequence":"additional","affiliation":[{"name":"Amsterdam UMC Locatie AMC  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0958-0286","authenticated-orcid":false,"given":"Matthew D","family":"Stachler","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003815005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.053"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300730"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2018.09.041"},{"key":"e_1_2_7_7_1","unstructured":"National Cancer Institute DCCPS Surveillance Research Program.Surveillance Epidemiology and End Results (SEER) Program.www.seer.cancer.gov."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001680"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.23511"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318985"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2019.05.004"},{"key":"e_1_2_7_12_1","first-page":"688","article-title":"Risk of cancer in patients with Barrett's esophagus","volume":"15","author":"Shaheen NJ","year":"2019","journal-title":"Gastroenterol. Hepatol."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.03.020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(21)00779-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.047"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1738"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0108"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-15-0130"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1768"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ffdd14"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200604000-00001"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816b6459"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2021.09.014"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20435"},{"key":"e_1_2_7_25_1","first-page":"1","article-title":"The SpaTemp cohort: 168 nondysplastic Barrett's esophagus surveillance patients with and without progression to early neoplasia to evaluate the distribution of biomarkers over space and time","volume":"18","author":"Frei NF","year":"2020","journal-title":"Dis. 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