{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T20:24:46Z","timestamp":1749414286161,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Tissue eosinophilia is commonly observed in T\u2010cell and classic Hodgkin lymphomas, but rarely in B\u2010cell lymphomas. Herein, we present the first report of a case series on nodal marginal zone lymphoma (NMZL) with tissue eosinophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>All 11 patients in this study had nodal disease at primary presentation. The mean age at diagnosis was 64\u2009years. The mean follow\u2010up period was 39\u2009months, and all patients were alive. Nine of the 11 patients (82%) showed no recurrence, but the other two patients experienced recurrence in the lymph nodes or skin. Marked eosinophilic infiltration was observed in all biopsied lymph nodes. Nine of the 11 patients had a preserved nodular architecture with expanded interfollicular areas. The other two patients showed diffuse lymphoma cell infiltration with effacement of nodal architecture. One of them was diagnosed as having diffuse large B\u2010cell lymphoma transformed from NMZL because large cells accounted for &gt;50% of the lymphoma cells and formed sheet\u2010like patterns. Cells were positive for CD20 and BCL2 and negative for CD5, CD10, and BCL6. Some patients showed myeloid cell nuclear differentiation antigen (MNDA) positivity. All patients showed B\u2010cell monoclonality via flow cytometry, southern blotting, and\/or polymerase chain reaction (PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All patients showed distinctive morphological features and could be misdiagnosed with peripheral T\u2010cell lymphoma due to their eosinophil\u2010rich backgrounds. The predominance of B cells, absence of histiocytes, and high endothelial venules in the interfollicular areas are key factors for diagnosis. B\u2010cell monoclonality is the most reliable evidence of differentiation. We designated this type of lymphoma as an eosinophil\u2010rich variant of NMZL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14963","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T09:37:37Z","timestamp":1684921057000},"page":"443-452","source":"Crossref","is-referenced-by-count":1,"title":["Eosinophil\u2010rich variant of nodal marginal zone lymphoma: a\u00a0clinicopathological study of 11 cases"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-4183","authenticated-orcid":false,"given":"Misayo","family":"Miyake","sequence":"first","affiliation":[{"name":"Department of Pathology The Jikei University School of Medicine  Tokyo Japan"},{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Sakata","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, 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