{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:11:55Z","timestamp":1780542715461,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The method of diagnosis of ductal carcinoma <jats:italic>in situ<\/jats:italic> (DCIS) has changed since the 1980s. The aim of this audit was to assess changes in the preoperative diagnosis of DCIS since the introduction of needle core biopsy, particularly the proportion with a preoperative biopsy diagnosis of DCIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The preoperative diagnoses of patients with a final diagnosis of DCIS in the surgical specimen were reviewed (i) in 809 patients who presented through breast screening from 1997 to 2021, and (ii) in all patients in 5 individual years at 5\u2010year intervals from 2000 to 2020 (254 in total). For screening\u2010detected DCIS the proportion with a preoperative diagnosis of DCIS increased from 75% to 98% over the study period. In a detailed analysis of all cases of DCIS in 5 separate years the proportion with a preoperative diagnosis of DCIS increased from 68% in 2000 to 96% in 2020. For high\u2010grade DCIS the proportion increased from 87% to 97%, and for low\u2010 or intermediate\u2010grade DCIS from 48% to 93%. The proportion of women who had vacuum\u2010assisted biopsy increased from 7% in 2000 to 58% in 2015. There was a small increase in the number of biopsies that had basal cytokeratin and oestrogen receptor immunohistochemistry to aid diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There has been an increase in the preoperative diagnosis of DCIS, particularly of low\u2010 or intermediate\u2010grade, over the last two decades. The increasing use of vacuum\u2010assisted biopsy is likely to be a major contributory factor to this increase.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.14994","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T01:09:23Z","timestamp":1687741763000},"page":"435-442","source":"Crossref","is-referenced-by-count":4,"title":["Preoperative diagnosis of ductal carcinoma <i>in situ<\/i> of the breast over a 24\u2010year period"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-4050","authenticated-orcid":false,"given":"Andrew H S","family":"Lee","sequence":"first","affiliation":[{"name":"Histopathology Department Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S","family":"Toss","sequence":"additional","affiliation":[{"name":"Histopathology Department Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J","family":"James","sequence":"additional","affiliation":[{"name":"Breast Institute, Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Hodi","sequence":"additional","affiliation":[{"name":"Histopathology Department Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O","family":"Ellis","sequence":"additional","affiliation":[{"name":"Histopathology Department Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5009-5525","authenticated-orcid":false,"given":"Emad A","family":"Rakha","sequence":"additional","affiliation":[{"name":"Histopathology Department Nottingham University Hospitals, City Hospital Campus  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-008-0067-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102368"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08060-z"},{"key":"e_1_2_10_5_1","volume-title":"Guidelines for non\u2010operative diagnostic procedures and reporting in breast cancer screening","author":"Non\u2010Operative Diagnosis Working Group of the UK National Coordinating Committee for Breast Pathology","year":"2021"},{"key":"e_1_2_10_6_1","volume-title":"Guidelines for non\u2010operative diagnostic procedures and reporting in breast cancer screening","author":"Non\u2010operative Diagnosis Subgroup of the National Coordinating Committee for Breast Screening Pathology","year":"2016"},{"key":"e_1_2_10_7_1","volume-title":"NHS Breast screening programme screening standards valid for data collected from 1 April 2021","year":"2021"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11110159"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-018-1781-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-007-9454-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.175.5.1751341"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01152-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-1262"},{"key":"e_1_2_10_14_1","volume-title":"Clinical guidance for breast cancer screening assessment","author":"NHS Breast Screening Programme","year":"2016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2015-203018"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.03786.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.05.024"},{"key":"e_1_2_10_18_1","volume-title":"Breast screening pathology audit for the screening period April 2016 to March 2019","year":"2020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00882.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199907)188:3<237::AID-PATH343>3.0.CO;2-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.7.733"},{"key":"e_1_2_10_22_1","volume-title":"Clinical guidelines for breast cancer screening assessment","author":"Wilson R","year":"2005"},{"key":"e_1_2_10_23_1","volume-title":"Clinical guidelines for breast cancer screening assessment","author":"Liston J","year":"2010"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.14994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T05:26:20Z","timestamp":1691645180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.14994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,25]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/his.14994"],"URL":"https:\/\/doi.org\/10.1111\/his.14994","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,25]]}}}