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These include incidental microscopic (flat) lesions known as pancreatic intra\u2010epithelial neoplasia and biliary intra\u2010epithelial neoplasia, and grossly visible, mass\u2010forming lesions (tumoral intra\u2010epithelial neoplasia) including intraductal papillary mucinous neoplasms, intraductal oncocytic papillary neoplasms, intraductal tubulopapillary neoplasms, intraductal papillary neoplasms of the bile duct and intracholecystic papillary neoplasms. Early detection and adequate treatment of these precursor lesions, especially the second group, have the potential to prevent pancreatobiliary cancer or at least improve its prognosis. In this review, we discuss their histopathology and recent updates on molecular profiling of these intraductal neoplasms of the pancreatobiliary tract.<\/jats:p>","DOI":"10.1111\/his.15003","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T04:50:30Z","timestamp":1689569430000},"page":"499-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intraductal neoplasms of the pancreatobiliary tract: navigating the alphabet"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7398-9356","authenticated-orcid":false,"given":"Yue","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Northwestern University  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olca","family":"Basturk","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine 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