{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:39:37Z","timestamp":1790145577439,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"\n Aims<\/jats:title>\n \n NUTM1<\/jats:italic>\n \u2010rearranged sarcoma is an emerging entity that differs from NUT carcinoma at the molecular level, with most of the former tumours harbouring fusions involving genes in the MYC\u2010associated factor X dimerization (\n MAD<\/jats:italic>\n ) transcription family (\n MXD1<\/jats:italic>\n ,\n MXD4<\/jats:italic>\n ,\n MXI1<\/jats:italic>\n [or\n MXD2<\/jats:italic>\n ], and\n MGA<\/jats:italic>\n ).\n MGA<\/jats:italic>\n ::\n NUTM1<\/jats:italic>\n is one of the most recently described novel gene fusions associated with NUTM1\u2010rearranged sarcoma. Herein we describe the clinicopathologic features of three sarcomas with an\n MGA<\/jats:italic>\n ::\n NUTM1<\/jats:italic>\n fusion.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n The three study patients were male, with an age range of 10\u201328\u2009years. The tumour sites were deep soft tissue of the thigh, the chest wall, and the pelvis. All three tumours were aggressive, with multiple recurrences and metastases. Histologically, the tumours were composed of monotonous spindle, round, or epithelioid cells in variably hyalinized stroma and prominent aggregates of amianthoid fibre\u2010like collagen or collagen rosettes. Mitotic activity was relatively low (5\u201312 mitotic figures per 10 hhpf). All tumours tested expressed NUT, with one tumour having S100 protein expression and two tumours having CD99 and CD56 expression. The genetic breakpoints were\n MGA<\/jats:italic>\n exon 21,\n MGA<\/jats:italic>\n exon 22, and\n NUTM1<\/jats:italic>\n exon 3.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n MGA<\/jats:italic>\n ::\n NUTM1<\/jats:italic>\n sarcoma often exhibits hyalinized stroma with amianthoid fibre\u2010like collagen or collagen rosettes in the presence of monotonous round, epithelioid, or spindle cell morphology. NUT immunohistochemistry and molecular testing can help confirm the diagnosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/his.15004","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T21:30:27Z","timestamp":1689283827000},"page":"712-721","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sarcoma with\n MGA<\/i>\n ::\n NUTM1<\/i>\n fusion: a report of three cases and literature review"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-698X","authenticated-orcid":false,"given":"Sintawat","family":"Wangsiricharoen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Paul E","family":"Wakely","sequence":"additional","affiliation":[{"name":"Department of Pathology Ohio State University Wexner Medical Center Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G","family":"Prieto","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"304","article-title":"BRD4\u2010NUT fusion oncogene: a novel mechanism in aggressive carcinoma","volume":"63","author":"French CA","year":"2003","journal-title":"Cancer 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