{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:59:39Z","timestamp":1792191579223,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    This review article examines some new and some problem areas in mesothelial pathology, four of which are discussed, as follows. (1) The concept of mesothelioma\n                    <jats:italic>in situ<\/jats:italic>\n                    : this lesion is defined as a single layer of bland mesothelial cells without evidence of invasion, but that have lost BAP1 and\/or MTAP by immunohistochemistry. Benign reactions can exactly mimic mesothelioma\n                    <jats:italic>in situ<\/jats:italic>\n                    , but a hint to the correct diagnosis is a story of recurrent pleural effusions\/ascites of unknown aetiology without radiological or direct visual evidence of tumour. (2) The nature of well\u2010differentiated papillary mesothelial tumour (WDPMT): WDPMT has a long history of arguments regarding its behaviour, and this uncertainty can now be seen to arise, in part, from the observation that some forms of mesothelioma\n                    <jats:italic>in situ<\/jats:italic>\n                    microscopically look exactly like WDPMT. Hence, it is recommended to always run at least a BAP1 stain on any lesion that looks like WDPMT. Both flat and WDPMT\u2010like mesothelioma\n                    <jats:italic>in situ<\/jats:italic>\n                    are strongly associated with eventual development of invasive mesothelioma, but this process is relatively slow. (3) New immunostains for separating mesothelioma from other tumours: here, it is proposed that in most cases, and particularly when the differential is epithelioid mesothelioma versus non\u2010small cell lung cancer, one can make this separation with extremely high sensitivity and specificity using just two stains: HEG1 and claudin\u20104. (4) Markers for separating benign from malignant mesothelial proliferations: this topic is briefly reviewed, with an indication of which markers are generally accepted and the best utilisation and possible limitations of each marker.\n                  <\/jats:p>","DOI":"10.1111\/his.15007","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T07:04:43Z","timestamp":1694415883000},"page":"136-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["New developments in mesothelial pathology"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4851-8517","authenticated-orcid":false,"given":"Andrew","family":"Churg","sequence":"first","affiliation":[{"name":"Department of Pathology Vancouver General Hospital, University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Thoracic tumors","author":"WHO Classification of Tumors Editorial Board","year":"2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.12.014"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-07153-2"},{"key":"e_1_2_11_5_1","volume-title":"Female Genital Tumors","author":"WHO Classification of Tumors Editorial Board","year":"2020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3520"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0804"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-4093"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01081-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2918"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12779"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001656"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/PO.19.00048"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/10935266211021222"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0646-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2021.100236"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-13061-3"},{"key":"e_1_2_11_18_1","first-page":"151","article-title":"The concept of mesothelioma in situ: implications for diagnosis and histogenesis","volume":"9","author":"Whitaker D","year":"1992","journal-title":"Semin. Diagn. Pathol."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0347-0"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20317"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.09.002"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03281-z"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.06.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2021.04.011"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25129"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.10.036"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2018.10.012"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0127-2"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14387"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.02.007"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10527"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061568"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200404000-00013"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00012"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000200"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-022-01082-y"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.001"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000002033"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900115)65:2<292::AID-CNCR2820650218>3.0.CO;2-W"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001507"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001712"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001792"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14783"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.99.003"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24475"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.04.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0112-RA"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001565"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.12.017"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100036"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22509"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000394"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0273-OA"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0310-0"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.45"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2022.11.013"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100030"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00920-9"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0331-OA"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.02.004"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0159-7"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001840"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0370-OA"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T21:35:53Z","timestamp":1703712953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,11]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/his.15007"],"URL":"https:\/\/doi.org\/10.1111\/his.15007","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,11]]},"assertion":[{"value":"2023-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}