{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:37:26Z","timestamp":1785875846557,"version":"3.56.0"},"reference-count":78,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>Myeloid\/lymphoid neoplasms with eosinophilia (M\/LN\u2010eo) and tyrosine kinase (TK) gene fusions are a rare group of haematopoietic neoplasms with a broad range of clinical and morphological presentations. Paediatric cases have increasingly been recognised. Importantly, not all appear as a chronic myeloid neoplasm and eosinophilia is not always present. In addition, standard cytogenetic and molecular methods may not be sufficient to diagnose M\/LN\u2010eo due to\u00a0cytogenetically cryptic aberrations. Therefore, additional evaluation with fluorescence <jats:italic>in\u2010situ<\/jats:italic> hybridisation and other molecular genetic techniques (array\u2010based comparative genomic hybridisation, RNA sequencing) are recommended for the identification of specific TK gene fusions. M\/LN\u2010eo with <jats:italic>JAK2<\/jats:italic> and <jats:italic>FLT3<\/jats:italic>\u2010rearrangements and <jats:italic>ETV6::ABL1<\/jats:italic> fusion were recently added as a formal member to this category in the International Consensus Classification (ICC) and the 5th edition of the WHO classification (WHO\u2010HAEM5). In addition, other less common defined genetic alterations involving TK genes have been described. This study is an update on M\/LN\u2010eo with TK gene fusions with focus on novel entities, as illustrated by cases submitted to the Bone Marrow Workshop, organised by the European Bone Marrow Working Group (EBMWG) within the frame of the 21st European Association for Haematopathology congress (EAHP\u2010SH) in Florence 2022. A literature review was performed including paediatric cases of M\/LN\u2010eo with TK gene fusions.<\/jats:p>","DOI":"10.1111\/his.15021","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T08:04:57Z","timestamp":1691481897000},"page":"829-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Myeloid\/lymphoid neoplasms with eosinophilia and tyrosine kinase fusion genes: A workshop report with focus on novel entities and a literature review including paediatric cases"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4357-1570","authenticated-orcid":false,"given":"Leonie","family":"Saft","sequence":"first","affiliation":[{"name":"Clinical Pathology and Cancer Diagnostics Karolinska University Laboratory, Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans 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