{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T18:37:43Z","timestamp":1771267063478,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Anastomosing haemangioma is a rare benign vascular neoplasm that may histologically mimic angiosarcoma. We report the largest single institution series of anastomosing haemangioma in the adrenal gland with emphasis on clinical and radiological features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Our laboratory information system was searched for a 25\u2010year period (1999\u20132023), yielding seven cases confirmed as anastomosing haemangioma of the adrenal gland after pathological\u00a0re\u2010review. Clinical, radiological and pathological information was obtained from medical charts and submitting pathologists. Of a total of seven patients, four (57.1%) were men and three women, ranging in age from 37 to 75\u2009years (mean\u2009=\u200961). Six of seven patients underwent adrenalectomies and one had radical nephrectomy. Tumours ranged from 0.7 to 6.4\u2009cm (mean\u2009=\u20092.1\u2009cm) and five of seven (71%) were grossly well\u2010circumscribed. Five of seven lesions were found incidentally at imaging for other indications. All tumours were unifocal except one, which presented with multifocal disease with a concurrent adjacent retroperitoneal anastomosing haemangioma. Three of five tumours imaged with contrast enhancement were almost completely hyperenhancing with a small central non\u2010enhancing portion, features overlapping with pheochromocytoma. One of seven tumours involved the peri\u2010adrenal adipose tissue with a focally infiltrative pattern. There were no recurrences or metastases in six patients with available follow\u2010up data (median\u2009=\u200995\u2009months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Benign anastomosing haemangiomas of the adrenal gland tend to occur in older patients, may mimic pheochromocytoma on imaging and must be distinguished from angiosarcoma pathologically. Better awareness of this entity by pathologists, radiologists and surgeons is crucial to appropriate work\u2010up, diagnosis and management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15022","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T06:02:02Z","timestamp":1691560922000},"page":"791-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anastomosing haemangioma of the adrenal gland: A\u00a0clinicopathological series of seven cases"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-5032","authenticated-orcid":false,"given":"Reza","family":"Alaghehbandan","sequence":"first","affiliation":[{"name":"Department of Anatomic Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick M","family":"Remer","sequence":"additional","affiliation":[{"name":"Section of Abdominal Imaging, Imaging Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eren","family":"Berber","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0851-1465","authenticated-orcid":false,"given":"Jesse K","family":"McKenney","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute Cleveland Clinic  Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ad30a7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000627"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318278817f"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPJPW34QCQYTMT"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2012.05.032"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182967e6c"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0690-2"},{"key":"e_1_2_8_9_1","first-page":"650","article-title":"Anastomosing hemangioma incidentally found in kidney or adrenal gland: study of 10 cases and review of literature","volume":"17","author":"Zhou J","year":"2020","journal-title":"Urol. 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