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Poroma and porocarcinoma are characterised by recurrent gene fusions involving <jats:italic>YAP1<\/jats:italic>, a transcriptional co\u2010activator, which is controlled by the Hippo signalling pathway. The fusion genes frequently involve <jats:italic>MAML2<\/jats:italic> and <jats:italic>NUTM1<\/jats:italic>, which are also rearranged in other cutaneous and extracutaneous neoplasms. We aimed to review the clinical, morphological and molecular features of this category of adnexal neoplasms with a special focus upon emerging differential diagnoses, and discuss how their systematic molecular characterisation may contribute to a standardisation of diagnosis, more accurate classification and, ultimately, refinement of their prognosis and therapeutic modalities.<\/jats:p>","DOI":"10.1111\/his.15023","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:15:58Z","timestamp":1692778558000},"page":"266-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Gene fusions in poroma, porocarcinoma and related adnexal skin tumours: An update"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2201-6914","authenticated-orcid":false,"given":"Thibault","family":"Kervarrec","sequence":"first","affiliation":[{"name":"CARADERM, French Network of 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