{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:52:24Z","timestamp":1787701944505,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Mesothelioma is a rare disease with an historically poor prognosis. Over the past decade, a grading system has been developed that is a powerful prognostic tool in epithelioid mesothelioma. Grading of epithelioid mesothelioma is now required or strongly recommended by expert consensus, the College of American Pathologists, the World Health Organization, and the International Mesothelioma Interest Group. The original nuclear grading system for epithelioid mesothelioma, developed in the United States, split epithelioid mesotheliomas into three prognostic groups with marked differences in survival. Now, this three\u2010tiered nuclear grading system has been combined with the presence or absence of necrosis to form the currently recommended two\u2010tiered grading system of low\u2010 and high\u2010grade epithelioid mesothelioma. This review will focus on the development of this grading system in mesothelioma, the grading system's shortcomings, and the application of the grading system to cytology specimens and other extra\u2010pleural sites. Lastly, this review will briefly discuss alternative grading systems and future considerations.<\/jats:p>","DOI":"10.1111\/his.15065","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T03:01:05Z","timestamp":1698116465000},"page":"153-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Updates on grading mesothelioma"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-0301","authenticated-orcid":false,"given":"Jefree J","family":"Schulte","sequence":"first","affiliation":[{"name":"The University of Wisconsin  Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya N","family":"Husain","sequence":"additional","affiliation":[{"name":"The University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5915"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/2049396712Y.0000000016"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0124-RA"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.06.024"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000616"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2016.12.017"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2018-0273-OA"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21928"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31826915f1"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.04.023"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.4.1122"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.146"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90026-2"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200205000-00002"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.05.002"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.170"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.08.2506"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14127"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001416"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.12.014"},{"key":"e_1_2_14_22_1","unstructured":"SchneiderF RodenR DacicS BakerTP.Cancer protocol templates.2021https:\/\/documents.cap.org\/protocols\/PleuraPericard_4.1.0.0.REL_CAPCP.pdf."},{"key":"e_1_2_14_23_1","volume-title":"Thoracic tumours","year":"2021"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0035-y"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-203993"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318211127a"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.39"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.06.020"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu227"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100232"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2015.121"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.06.024"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0215-RA"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0331-OA"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2022.1549"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqad041"},{"issue":"2","key":"e_1_2_14_37_1","first-page":"1318","article-title":"USCAP 2022 abstracts: pulmonary, mediastinal, pleural, and peritoneal pathology (1187\u20101248)","volume":"35","year":"2022","journal-title":"Mod. 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