{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:45:21Z","timestamp":1792525521743,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Recently, <jats:italic>HMGA2::WIF1<\/jats:italic> fusion has been reported in pleomorphic adenoma (PAs) originating from the parotid gland with a characteristic canalicular adenoma (CAA)\u2010like pattern. However, it is unclear whether <jats:italic>HMGA2::WIF1<\/jats:italic> fusion may occur in salivary gland carcinoma or tumours originating from the minor salivary glands. We herein conducted a detailed clinicopathological review of eight salivary gland tumours harbouring <jats:italic>HMGA2::WIF1<\/jats:italic> fusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The reviewed diagnoses of salivary gland neoplasms with <jats:italic>HMGA2::WIF1<\/jats:italic> fusion were PA (<jats:italic>n<\/jats:italic>\u2009=\u2009four), myoepithelioma (<jats:italic>n<\/jats:italic>\u2009=\u2009one), myoepithelial carcinoma ex PA (<jats:italic>n<\/jats:italic>\u2009=\u2009two) and high\u2010grade carcinoma with basaloid features (<jats:italic>n<\/jats:italic>\u2009=\u2009one). Two tumours originated from the minor salivary glands. Six tumours (80%) contained areas reminiscent of CAA characterised by interconnected trabeculae\/canaliculi of monotonous oncocytic or cuboidal tumour cells associated with a hypocellular, hyalinised to myxoid stroma. Areas typical of PA were seen in four (50%) cases. All tumours showed diffuse S100 and CK7 immunopositivity. Adverse events were detected in two cases, including local recurrence in a patient with PA, and local and distant recurrences and disease\u2010related death in a patient with a high\u2010grade carcinoma of the minor salivary gland of the buccal\u00a0space, showing tumour necrosis and perineural invasion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary gland neoplasms with <jats:italic>HMGA2::WIF1<\/jats:italic> fusion are predominantly characterised by CAA\/striated duct adenoma\u2010like histology and a S100+\/CK7+ immunoprofile. These tumours are not always benign, as among all reported cases approximately 20% showed malignancy (six of 28) and adverse outcome (three of 15), including recurrence, distant metastasis and disease\u2010specific mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15074","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T07:24:34Z","timestamp":1697613874000},"page":"387-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Expanding the histological spectrum of salivary gland neoplasms with <i>HMGA2::WIF1<\/i> fusion emphasising their malignant potential: a report of eight cases"],"prefix":"10.1111","volume":"84","author":[{"given":"Nora","family":"Katabi","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-0871","authenticated-orcid":false,"given":"Purvil","family":"Sukhadia","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"DiNapoli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Sinai Health System  Toronto ON Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-9835","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY 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