{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:27:22Z","timestamp":1764937642068,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Follicular helper T\u2010cell (TFH) lymphoma of the angioimmunoblastic\u2010type (AITL), one of the most prevalent T\u2010cell lymphomas, typically encompasses proliferation of high endothelial venules and Epstein\u2013Barr virus\u2010positive immunoblasts, but neither infection with HHV8 nor association with Kaposi's sarcoma (KS) have been described. The aims of this study are to characterise the association between AITL and HHV8 infection or KS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Three male patients aged 49\u201376\u2009years, HIV\u2010negative, with concurrent nodal involvement by AITL and KS, were identified from our files and carefully studied. Two patients originated from countries where endemic KS occurs, including one with cutaneous KS. The lymphomas featured abundant vessels, expanded follicular dendritic cells and neoplastic TFH cells [PD1+ (three of three), ICOS+ (three of three), CXCL13+ (three of three), CD10<jats:sup>+<\/jats:sup> (two of three), BCL6 (two of three)] but lacked EBV+ immunoblasts. The foci of KS consisted of subcapsular proliferations of ERG+, CD31<jats:sup>+<\/jats:sup> and\/or CD34<jats:sup>+<\/jats:sup>, HHV8+ spindle cells. High\u2010throughput sequencing showed AITL\u2010associated mutations in <jats:italic>TET2<\/jats:italic> (three of three), <jats:italic>RHOA<\/jats:italic> (<jats:italic>G17V<\/jats:italic>) (three of three) and <jats:italic>IDH2<\/jats:italic> (<jats:italic>R172<\/jats:italic>) (two of three), which were absent in the microdissected KS component in two cases. Relapses in two patients consisted of AITL, without evidence of KS. No evidence of HHV8 infection was found in a control group of 23 AITL cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Concurrent nodal involvement by AITL and KS is rare and identification of both neoplastic components may pose diagnostic challenges. The question of whether the association between AITL and KS may be fortuitous or could reflect the underlying immune dysfunction in AITL remains open.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15083","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T19:48:01Z","timestamp":1700682481000},"page":"556-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Angioimmunoblastic T\u2010cell lymphoma and Kaposi sarcoma: A fortuitous collision?"],"prefix":"10.1111","volume":"84","author":[{"given":"Elsa","family":"Poullot","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pathologie H\u00f4pitaux Universitaires Henri Mondor, AP\u2010HP  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est Cr\u00e9teil  Cr\u00e9teil France"},{"name":"INSERMU955, Institut Mondor de Recherche Biom\u00e9dicale  Cr\u00e9teil 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