{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:47:26Z","timestamp":1789472846909,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Diagnosis of mesothelioma <jats:italic>in situ<\/jats:italic> (MIS) is historically controversial and, until recently, specific features defining the entity have not been well characterized. Most reported cases of MIS occurred in the pleura; peritoneal MIS is very rare. This study investigates the morphologic features and results of ancillary testing in peritoneal MIS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present three patients with peritoneal\u00a0MIS, as defined by a single layer of mesothelial cells with loss of nuclear BRCA\u20101\u2010associated protein\u20101 (BAP1) immunostaining and without evidence of invasive tumour by microscopic evaluation, imaging, or direct examination of the peritoneum. Histology and immunostains were reviewed by three expert thoracic pathologists with multidisciplinary input. Next\u2010generation sequencing (NGS) was performed in all three cases. A literature review was conducted to characterize this rare precursor lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BAP1 was lost in all three lesions, while methylthioadenosine phosphorylase (MTAP) was retained in two (not performed in the third). NGS revealed <jats:italic>BAP1<\/jats:italic> pathogenic alterations in all three cases as well as mutations of <jats:italic>SMO<\/jats:italic>, <jats:italic>ERCC3<\/jats:italic>, <jats:italic>TET2<\/jats:italic>, and <jats:italic>U2AF1<\/jats:italic>. Progression to invasive mesothelioma occurred in one patient at 13\u2009months postdiagnosis (case 1). One patient was diagnosed at age 24 and was later found to harbour a <jats:italic>BAP1<\/jats:italic> germline mutation (case 3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This work describes the histologic features and clinicopathologic characteristics of peritoneal MIS in three cases, highlights <jats:italic>BAP1<\/jats:italic> somatic and germline mutations in peritoneal MIS, and strengthens the importance of ancillary studies (including immunohistochemical and molecular studies) in the diagnosis of MIS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15092","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:56:06Z","timestamp":1702425366000},"page":"492-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mesothelioma <i>in situ<\/i> of the peritoneum: report of three cases and review of the literature"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5795-7183","authenticated-orcid":false,"given":"Emily","family":"Symes","sequence":"first","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Tjota","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Cody","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pittsburgh Medical Center  Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedy","family":"Kindler","sequence":"additional","affiliation":[{"name":"Section of Hematology\/Oncology, Department of Medicine University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Mitchell","sequence":"additional","affiliation":[{"name":"University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunter","family":"Witmer","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Turaga","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Chicago  Chicago IL USA"},{"name":"Department of Surgery Yale Cancer Center  New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Krausz","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliya N.","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago IL USA"},{"name":"Department of Pathology Duke University Medical Center  Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.12.005"},{"key":"e_1_2_8_3_1","volume-title":"Pathology and genetics of tumours of the lung, pleura, thymus and heart","author":"Borczuk AC","year":"2021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.12.014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0347-0"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000394"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.07.012"},{"key":"e_1_2_8_8_1","article-title":"Bilateral pleural mesothelioma in situ and peritoneal mesothelioma in situ associated with BAP1 germline mutation: a case report","volume":"3","author":"MacLean A","year":"2022","journal-title":"JTO Clin. 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