{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T09:46:43Z","timestamp":1794649603931,"version":"4.9.1"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The distinction of high\u2010grade prostate cancer (PCa) from poorly differentiated urothelial carcinoma (UC) can be somewhat challenging on clinical and morphological grounds alone, yet it is of great importance for prognostication and choice of treatment. GATA3 is a useful immunohistochemical marker to confirm urothelial origin. However, recent works report strong GATA3 immunoexpression in primary high\u2010grade PCa. The aim of this study was to explore GATA3 expression specifically in metastatic PCa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The pathology databases of four tertiary institutions were queried for cases of metastatic PCa. Available slides and clinical records were reviewed by experienced genitourinary pathologists. Prostatic markers (PSA, PSAP, NKX3.1) and GATA3 immunohistochemistry were performed. A total of 163 metastatic PCa cases were included. At least one prostate marker was positive in each case of non\u2010regional distant metastasis, confirming prostatic origin. GATA3 strong staining was found in four (2.5%) cases: two liver, one bone and one non\u2010regional lymph\u2010node metastases. All four patients had Grade Group 5 PCa at the initial diagnosis. The metastatic prostatic adenocarcinomas were solid, either with no gland formation (<jats:italic>n<\/jats:italic>\u2009=\u20093) or with only focal cribriforming (<jats:italic>n<\/jats:italic>\u2009=\u20091).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first study exploring GATA3 expression specifically in metastatic PCa. Despite being infrequent, GATA3 positivity in high\u2010grade PCa may lead to misdiagnosis, with clinical implications. We recommend a panel of immunohistochemical markers, both prostatic and urothelial, for ruling out UC, either in primary tumour samples or in the event of metastases of unknown primary, when a genitourinary origin is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15094","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:03:39Z","timestamp":1700082219000},"page":"507-514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Aberrant expression of GATA3 in metastatic adenocarcinoma of the prostate: an important pitfall"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-1391","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Lobo","sequence":"first","affiliation":[{"name":"Department of Pathology Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC)  Porto Portugal"},{"name":"Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI\u2010IPOP) Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center Raquel Seruca (P.CCC) &amp; RISE@CI\u2010IPOP (Health Research Network)  Porto Portugal"},{"name":"Department of Pathology and Molecular Immunology ICBAS \u2013 School of Medicine and Biomedical Sciences, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-7292","authenticated-orcid":false,"given":"Nazario P","family":"Tenace","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e0 Vita\u2010Salute San Raffaele  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Ca\u00f1ete\u2010Portillo","sequence":"additional","affiliation":[{"name":"Department of Pathology Heersink School of Medicine, The University of Alabama at Birmingham  Birmingham AL 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Comprehensive Cancer Center Raquel Seruca (P.CCC) &amp; RISE@CI\u2010IPOP (Health Research Network)  Porto Portugal"},{"name":"Department of Pathology and Molecular Immunology ICBAS \u2013 School of Medicine and Biomedical Sciences, University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Lucian\u00f2","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e0 Vita\u2010Salute San Raffaele  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara R","family":"Harik","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Emory University School of Medicine  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-3797","authenticated-orcid":false,"given":"Cristina","family":"Magi\u2010Galluzzi","sequence":"additional","affiliation":[{"name":"Department of Pathology 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