{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T23:25:19Z","timestamp":1792970719004,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Oncogenic <jats:italic>FGFR1\/2\/3<\/jats:italic> rearrangements are found in various cancers. Reported cases in head and neck (HN) are mainly squamous cell carcinomas (SCCs) with <jats:italic>FGFR3<\/jats:italic>::<jats:italic>TACC3<\/jats:italic> fusions, a subset of which also harbour high\u2010risk human papillomavirus (HPV). However, the knowledge of the clinicopathological spectrum of <jats:italic>FGFR<\/jats:italic>\u2010rearranged head and neck carcinomas (FHNC) is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A retrospective MSK\u2010fusion clinical sequencing cohort 2016\u201323 was searched to identify malignant tumours in the HN region harbouring <jats:italic>FGFR1\/2\/3<\/jats:italic> fusion. FHNC were characterised by histological examination, immunohistochemistry and molecular analysis. Electronic medical records were reviewed. Three FHNC were identified. Two cases (cases 1 and 2) involved sinonasal tract and were high\u2010grade carcinomas with squamous, basaloid, glandular and\/or ductal\u2013myoepithelial features. Case 1 arose in a 79\u2010year\u2010old man and harboured <jats:italic>FGFR2<\/jats:italic>::<jats:italic>KIF1A<\/jats:italic> fusion. Case 2 arose in a 58\u2010year\u2010old man, appeared as HPV\u2010related multiphenotypic sinonasal carcinoma (HMSC), and was positive for <jats:italic>FGFR2<\/jats:italic>::<jats:italic>TACC2<\/jats:italic> fusion and concurrent high\u2010risk HPV, non\u2010type 16\/18. Case 3 was <jats:italic>FGFR3<\/jats:italic>::<jats:italic>TACC3<\/jats:italic> fusion\u2010positive keratinising SCCs arising in the parotid of a 60\u2010year\u2010old man. All three cases presented at stage T4. Clinical follow\u2010up was available in two cases; case 1 remained disease\u2010free for 41\u2009months post\u2010treatment and case 3 died of disease 2\u2009months after the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FHNC include a morphological spectrum of carcinomas with squamous features and may occur in different HN locations, such as parotid gland and the sinonasal tract. Sinonasal cases can harbour <jats:italic>FGFR2<\/jats:italic> rearrangement with or without associated high\u2010risk HPV. Timely recognition of FHNC could help select patients potentially amenable to targeted therapy with FGFR inhibitors. Further studies are needed (1) to determine if <jats:italic>FGFR2<\/jats:italic> rearranged\/HPV\u2010positive sinonasal carcinomas are biologically distinct from HMSC, and (2) to elucidate the biological and clinical significance of <jats:italic>FGFR2<\/jats:italic> rearrangement in the context of high\u2010risk HPV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15099","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:55:27Z","timestamp":1701132927000},"page":"589-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>FGFR1\/2\/3<\/i>\u2010rearranged carcinoma of the head and neck: expanded histological spectrum crossing path with high\u2010risk <scp>HPV<\/scp> in the sinonasal tract"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8289-7418","authenticated-orcid":false,"given":"Ying\u2010Hsia","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Mullaney","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E","family":"DiNapoli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Head and Neck Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-9835","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Katabi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-8946","authenticated-orcid":false,"given":"Snjezana","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-01157-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000615"},{"key":"e_1_2_8_4_1","first-page":"1970","article-title":"Chromosome translocations, gene fusions, and their molecular consequences in pleomorphic salivary gland adenomas","volume":"10","author":"Stenman 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