{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:01:19Z","timestamp":1788289279455,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Primary mucinous adenocarcinoma of the urethra represents an extremely rare entity. We sought to characterise further these tumours\u2019 clinicopathological, immunohistochemical and molecular features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Thirty\u2010five cases were identified, occurring in 18 males and 17 females. The mean age at diagnosis was 65\u2009years (28\u201389\u2009years). The main presentation symptoms were haematuria and urinary outlet obstruction. Microscopic analysis revealed that all 35 tumours have stromal dissection by mucin. Ten tumours showed villoglandular dysplasia, nine showed mucinous metaplasia, two showed adenocarcinoma <jats:italic>in situ<\/jats:italic> and four showed signet ring cell features. All tumours were immunopositive for CEA, while immunonegative for nuclear \u03b2\u2010catenin; 19 of 23 (83%) expressed high molecular weight cytokeratin; 19 of 33 (58%) CK7; 28 of 34 (82%) CK20; 32 of 35 (91%) CDX2; 22 of 27 (81%) cadherin\u201017 (CDH\u201017); 26 of 29 (90%) SATB2; and one of 31 (3%) GATA3. Mismatch repair gene products, including MLH1, PMS2, MSH2 and MSH6, were immunopositive, suggesting the MSI\u2010low genotype of mucinous adenocarcinoma of the urethra. BRAF V600E and ALK rearrangements were not detected. During the mean follow\u2010up of 20\u2009months, nine patients either developed distant metastasis or succumbed to the illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study, encompassing the most extensive series of 35 cases of primary mucinous adenocarcinoma of the urethra, provides crucial insights into its precise diagnosis, management and potential targeted treatments. We found a greater CDX2, SATB2 and CDH17 sensitivity in these urethral tumours for the first time, to our knowledge. We identified characteristics such as an MSI\u2010low profile, non\u2010V600E BRAF mutations and an absence of ALK rearrangements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15118","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T02:17:16Z","timestamp":1703038636000},"page":"753-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary mucinous adenocarcinoma of the urethra: A\u00a0clinicopathological analysis of 35 cases"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1941-2178","authenticated-orcid":false,"given":"Rongbin","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology Washington University in St Louis  St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Peking University Third Hospital Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changzheng Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Urology, Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Urology Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urologic Surgery, Beth Israel Deaconess Medical Center Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lopez\u2010Beltran","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences Cordoba University Medical School  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Brown University Warren Alpert Medical School, Lifespan Academic Medical Center and the Legorreta Cancer Center at Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.09.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31802ff7c4"},{"key":"e_1_2_9_4_1","first-page":"147","article-title":"Primary carcinomas of the urethra","volume":"14","author":"Amin MB","year":"1997","journal-title":"Semin. 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