{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:28:25Z","timestamp":1790872105764,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T00:00:00Z","timestamp":1705881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Histological chorioamnionitis (HCA) is a condition linked to preterm birth and neonatal infection and its relationship with various pathological stages in extremely preterm neonates, and with their associated short\u2010 and long\u2010term consequences, remains a subject of research. This study investigated the connection between different pathological stages of HCA and both short\u2010term complications and long\u2010term outcomes in preterm infants born at or before 32\u2009weeks of gestational age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm infants born at \u2264\u200932\u2009weeks of gestation who underwent placental pathology evaluation and were followed\u2010up at 18\u201324\u2009months of corrected age were included. Neonates were classified based on their exposure to HCA and were further subdivided into different groups according to maternal inflammatory responses (MIR) and fetal inflammatory responses (FIR) stages. We compared short\u2010term complications during their hospital stay between the HCA\u2010exposed and \u2010unexposed groups and examined the influence of HCA stages on long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HCA group exhibited distinct characteristics such as higher rates of premature rupture of membranes &gt;\u200918\u2009h, reduced amniotic fluid, early\u2010onset sepsis, bronchopulmonary dysplasia and intraventricular haemorrhage (IVH) grades III\u2013IV (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The moderate\u2013severe HCA group displayed lower gestational age, lower birth weight and higher incidence of IVH (grades III\u2013IV) and preterm sepsis compared with the mild HCA group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). After adjusting for confounders, the MIR stages 2\u20133 group showed associations with cognitive impairment and cerebral palsy (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the FIR stages 2\u20133 group also showed poor long\u2010term outcomes and cognitive impairment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderate\u2013severe HCA was associated with increased early\u2010onset sepsis, severe IVH and poor long\u2010term outcomes, including cognitive impairment and cerebral palsy. Vigilant prevention strategies are warranted for severe HCA cases in order to mitigate poorer clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15147","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T04:30:34Z","timestamp":1705984234000},"page":"1024-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Histological chorioamnionitis and pathological stages on very preterm infant outcomes"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2935-2878","authenticated-orcid":false,"given":"Jiajia","family":"Duan","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falin","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoya","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingbing","family":"Li","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xirui","family":"Peng","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Department of Pediatrics Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Center for Perinatal Medicine and Health, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Women's and Children's Health Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37932"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.02.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.833121"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.13"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.11.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1281904"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2022.2131388"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.722489"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101146"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2303347"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21713"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018229"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01633-0"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2020.11.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.00595"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113914"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.10.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2018.0102"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-020-00895-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0225-CC"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.056"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2017.09.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201812-2348OC"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02459-w"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02562-y"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073819840449"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijns5010007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.938228"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/injuryprev-2016-042031"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24677"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-019-0322-0"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.15715"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1618824"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.846313"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-00431770366"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2014-0035"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2013.56.4.227"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15803"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.08.007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004377"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.042"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.03.021"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.11.006"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.09.010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.001"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.4248"},{"key":"e_1_2_8_49_1","first-page":"e481","article-title":"Placental pathology and long\u2010term neurodevelopment of very preterm infants","volume":"206","author":"Vliet E","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001246"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:32:09Z","timestamp":1718940729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,22]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/his.15147"],"URL":"https:\/\/doi.org\/10.1111\/his.15147","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,22]]},"assertion":[{"value":"2023-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}