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This meta\u2010analysis aims to review and examine the prognostic role of tumour budding specifically in noncolorectal gastrointestinal and pancreatobiliary tract cancers, broadening our perspective on its clinical relevance. The literature review was conducted through PubMed, Embase, and Web of Science from inception till 20 February 2023. Pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were calculated to assess the relation between tumour budding and clinicopathologic features, as well as overall survival. Each study was evaluated using the Newcastle\u2010Ottawa Scale and both heterogeneity and publication bias were analysed. In this meta\u2010analysis of 57 studies across various cancer types, multivariate HR revealed worse overall survival in oesophageal squamous cell carcinoma (HR 3.34 [95% CI 2.21\u20135.04]), gastric adenocarcinoma (2.03 [1.38\u20132.99]), pancreatic ductal adenocarcinoma (2.56 [2.02\u20133.25]), and biliary tract adenocarcinoma (3.11 [2.46\u20133.93]) with high\u2010grade tumour budding. Additionally, high\u2010grade tumour budding consistently correlated with adverse clinicopathological features, including lymph node metastasis, lymphovascular invasion, and distant metastasis without any observed inverse association. High heterogeneity was noted. Our study suggests that tumour budding is a valuable prognostic marker in various cancers. Nonetheless, standardized criteria tailored to specific organ types are necessary to enhance its clinical utility.<\/jats:p>","DOI":"10.1111\/his.15154","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:05:10Z","timestamp":1708077910000},"page":"1079-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-0070","authenticated-orcid":false,"given":"Ji Hyun","family":"Park","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Il","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics 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