{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:08:32Z","timestamp":1789171712174,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Carcinomas of the seminal vesicle are exceedingly rare, with a limited number of cases described in the literature. Reported cases span a relatively wide morphological spectrum, and their genomic features remain unexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>In this study, we interrogated five primary epithelial neoplasms of the seminal vesicle using a targeted DNA sequencing platform (OncoPanel, 447 genes).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The tumours included one adenocarcinoma with intestinal phenotype presenting after external beam radiation (for prostatic adenocarcinoma), one carcinoma with M\u00fcllerian\u2010type clear cell phenotype, two mucinous tumours resembling low\u2010grade mucinous neoplasms of the appendix (LAMN) and one mucinous cystadenoma. The post\u2010radiation mucinous adenocarcinoma had genomic findings consistent with bi\u2010allelic inactivation of <jats:italic>TP53<\/jats:italic>, as well as multiple copy\u2010number changes with regional and chromosomal arm\u2010level copy\u2010number losses. The M\u00fcllerian\u2010type clear cell carcinoma exhibited a complex copy\u2010number profile with numerous regional and arm\u2010level copy\u2010number changes, as well as focal amplification events, including copy\u2010number gain of 8q and amplification of a region within 20q13. Both low\u2010grade mucinous tumours resembling LAMN harboured hot\u2010spot gain\u2010of\u2010function <jats:italic>KRAS<\/jats:italic> variants (p.G12V and p.G13D) as the only genomic alteration. No genomic alterations were detected inthe lesion diagnosed as mucinous cystadenoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that primary low\u2010grade mucinous neoplasms of the seminal vesicle may represent a distinct entity equivalent to appendiceal counterparts, driven by gain\u2010of\u2010function variants of RAS GTPases. The remaining tumours showed genomic features that closely resembled those of neoplasms with comparable\u00a0phenotypes and\/or biological characteristics arising in other sites, suggesting that they could be managed similarly, with special considerations related to their anatomical location.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15167","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T06:09:50Z","timestamp":1709014190000},"page":"1192-1198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genomic analysis of primary epithelial neoplasms of the seminal vesicle identifies a subset of mucinous cystic tumours driven by KRAS mutations"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"first","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-1846","authenticated-orcid":false,"given":"Laurence A","family":"Galea","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Melbourne Pathology, Sonic Healthcare  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Foroughi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology QML Pathology  Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E","family":"Siegmund","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-7831","authenticated-orcid":false,"given":"William J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital and Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sree","family":"Appu","sequence":"additional","affiliation":[{"name":"Department of Surgery Monash University  Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad T","family":"Idrees","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Ulbright","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-6331","authenticated-orcid":false,"given":"Andres M","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University School of Medicine  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000057"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14425"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14800"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15036"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0527-OA"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.87062"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00264-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.186"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000246"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13986"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi356"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3567"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-001656"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205242"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4947"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T10:26:02Z","timestamp":1713954362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/his.15167"],"URL":"https:\/\/doi.org\/10.1111\/his.15167","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"2023-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}