{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:44:18Z","timestamp":1789047858181,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to assess the oncological impact of micrometric extent of invasion in patients with pT1 bladder cancer (BCa) who underwent <jats:italic>en\u2010bloc<\/jats:italic> resection for bladder tumour (ERBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We retrospectively analysed the records and specimens of 106 pT1 high\u2010grade BCa patients who underwent ERBT. The extent of invasion, such as depth from basal membrane, number of invasive foci, maximum width of invasive focus, muscularis mucosae invasion and infiltration pattern (pattern A: solid sheet\u2010like, nodular or nested growth, pattern B: trabecular, small cluster or single\u2010cell pattern) were evaluated by a single genitourinary pathologist. The end\u2010points were recurrence\u2010free (RFS) and progression\u2010free survival (PFS). Within a median follow\u2010up of 23\u2009months, overall, 36 patients experienced recurrence and 13 patients experienced disease progression. The 2\u2010year PFS differed significantly depending on depth from basal membrane (&lt;\u20091.3\u2009mm: 94.8% versus \u2267\u20091.3\u2009mm: 65.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), maximum width of invasive focus (&lt;\u20094\u2009mm: 91.7% versus \u2267\u20094\u2009mm: 62.3%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), muscularis mucosae (MM) invasion (above MM\u2009=\u200996.1% versus into or beyond MM\u2009=\u200964.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and infiltration pattern (pattern A: 100% versus pattern B: 83.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.037). In a multivariable analysis, MM invasion [hazard ratio (HR)\u2009=\u20094.54, 95% confidence interval (CI)\u2009=\u20091.25\u201316.5] and maximum width of invasive focus\u2009\u2267\u20094\u2009mm (HR\u2009=\u20094.79, 95% CI\u2009=\u20091.25\u201316.5) were independent prognostic factors of progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>En\u2010bloc<\/jats:italic> resection facilitates the evaluation of pathologic variables that might be useful in predicting disease recurrence and progression. In particular, not only the MM invasion but also the maximum width of invasion focus, reflecting the invasive volume, appear to be reliable prognosticators for disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15177","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T10:31:07Z","timestamp":1710325867000},"page":"92-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of micrometric substaging in pT1 bladder cancer patients treated with <i>en\u2010bloc<\/i> transurethral resection"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7410-0712","authenticated-orcid":false,"given":"Takafumi","family":"Yanagisawa","sequence":"first","affiliation":[{"name":"Department of Urology The Jikei University School of Medicine  Tokyo Japan"},{"name":"Department of Urology, Comprehensive Cancer Center Medical University of Vienna  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