{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:16:34Z","timestamp":1792030594781,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Classification of renal neoplasms on small tissue biopsies is in increasing demand, and maintaining broad differential diagnostic considerations in this setting is necessary. When evaluating a renal or perirenal tumour biopsy with sarcomatoid morphology, together with sarcomatoid renal cell carcinoma and sarcomatoid urothelial carcinoma as top diagnostic considerations, it is vital to additionally consider the possibility of well\u2010differentiated and de\u2010differentiated liposarcoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      This study reports a series of 30 biopsy samples from sites in or around the kidney collected from four institutions in which the correct diagnosis was either well\u2010differentiated or de\u2010differentiated liposarcoma. The majority (26 of 30, 87%) of lesions were accurately diagnosed on biopsy sampling, all of which incorporated testing for MDM2 by immunohistochemistry (IHC), fluorescence\n                      <jats:italic>in\u2010situ<\/jats:italic>\n                      hybridisation (FISH) or a combination of the two as part of the diagnostic work\u2010up. Tumour expression of MDM2 by IHC without confirmatory FISH analysis was sometimes (30%) sufficient to reach a diagnosis, but demonstration of\n                      <jats:italic>MDM2<\/jats:italic>\n                      amplification by FISH was ascertained in the majority (57%) of biopsy samples. A diagnosis of de\u2010differentiated liposarcoma was not definitively established until resection in four (13%) patients, as no MDM2 testing was performed on the corresponding pre\u2010operative biopsies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When a retroperitoneal tumour is not clinically suspected, histological consideration of a liposarcoma diagnosis may be overlooked. Implementation of ancillary immunohistochemical and cytogenetic testing can ultimately lead to a definitive diagnosis in this potentially misleading anatomical location.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15197","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T04:25:30Z","timestamp":1713759930000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnosing liposarcoma on (peri)\u2010renal mass biopsy: A clinicopathological study of 30 cases"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7948-2337","authenticated-orcid":false,"given":"Susan K","family":"Potterveld","sequence":"first","affiliation":[{"name":"Department of Pathology Stanford Medical Center  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysha","family":"Mubeen","sequence":"additional","affiliation":[{"name":"University of New Mexico  Albuquerque NM USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-7831","authenticated-orcid":false,"given":"William J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Clay","sequence":"additional","affiliation":[{"name":"University of Colorado  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Bourgeau","sequence":"additional","affiliation":[{"name":"University of Colorado  Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-2704","authenticated-orcid":false,"given":"Gregory W","family":"Charville","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford Medical Center  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur R","family":"Sangoi","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford Medical Center  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000001911"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.2341"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.04.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.09.032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.11.029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2018.04.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969221133356"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13752"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318180c899"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.02.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02703-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000366"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000910"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.12.025"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0815-x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03707.x"},{"key":"e_1_2_8_18_1","article-title":"A large retroperitoneal liposarcoma mimicking an angiomyolipoma on pre\u2010operative imaging: a case report","volume":"15","author":"Usuga D","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8812057"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02813-9"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.01.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-022-03662-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2019.02.005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2023.102523"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000737"},{"key":"e_1_2_8_26_1","first-page":"189","article-title":"Kidney hibernoma: case report and literature review","volume":"82","author":"Delsignore A","year":"2010","journal-title":"Arch. 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