{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:00:32Z","timestamp":1785578432897,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001445","name":"Alex's Lemonade Stand Foundation for Childhood Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001445","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      B lymphoblastic leukaemia\/lymphoma (B\u2010ALL) is thought to originate from Pro\/Pre\u2010B cells and the genetic aberrations largely reside in lymphoid\u2010committed cells. A recent study demonstrated that a proportion of paediatric B\u2010ALL patients have\n                      <jats:italic>BCR<\/jats:italic>\n                      ::\n                      <jats:italic>ABL1<\/jats:italic>\n                      fusion in myeloid cells, suggesting a chronic myeloid leukaemia (CML)\u2010like biology in this peculiar subset of B\u2010ALL, although it is not entirely clear if the CD19\u2010negative precursor compartment is a source of the myeloid cells. Moreover, the observation has not yet been extended to other fusion\u2010driven B\u2010ALLs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      In this study we investigated a cohort of\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged B\u2010ALL patients with a comparison to\n                      <jats:italic>BCR<\/jats:italic>\n                      ::\n                      <jats:italic>ABL1<\/jats:italic>\n                      \u2010rearranged B\u2010ALL by performing cell sorting via flow cytometry followed by FISH (fluorescence\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization) analysis on each of the sorted populations. In addition, RNA sequencing was performed on one of the sorted populations. These analyses showed that (1) multilineage involvement was present in 53% of\n                      <jats:italic>BCR<\/jats:italic>\n                      ::\n                      <jats:italic>ABL1<\/jats:italic>\n                      and 36% of\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged B\u2010ALL regardless of age, (2) multilineage involvement created pitfalls for residual disease monitoring, and (3) HSPC transcriptome signatures were upregulated in\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged B\u2010ALL with multilineage involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      In summary, multilineage involvement is common in both\n                      <jats:italic>BCR<\/jats:italic>\n                      ::\n                      <jats:italic>ABL1<\/jats:italic>\n                      \u2010rearranged and\n                      <jats:italic>KMT2A<\/jats:italic>\n                      \u2010rearranged B\u2010ALL, which should be taken into consideration when interpreting the disease burden during the clinical course.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15203","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:14:30Z","timestamp":1714454070000},"page":"310-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multilineage involvement in\n                    <i>KMT2A<\/i>\n                    \u2010rearranged B acute lymphoblastic leukaemia: cell\u2010of\u2010origin, biology, and clinical implications"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2226-6163","authenticated-orcid":false,"given":"Umut","family":"Aypar","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Dilip","sequence":"additional","affiliation":[{"name":"Center for Epigenetics Research Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramya","family":"Gadde","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dory M","family":"Londono","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9167-3205","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B","family":"Geyer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leukemia Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Derkach","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cytogenetics Laboratory Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob L","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Medicine, Leukemia Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Roshal","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Hematopathology Service Memorial Sloan Kettering Cancer Center  New York NY 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