{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:30:02Z","timestamp":1790022602057,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>\n                      Head and neck nuclear protein of testis carcinoma (HN\u2010NUT) is a rare form of carcinoma diagnosed by NUT immunohistochemistry positivity and\/or\n                      <jats:italic>NUTM1<\/jats:italic>\n                      translocation. Although the prototype of HN\u2010NUT is a primitive undifferentiated round cell tumour (URC) with immunopositivity for squamous markers, it is our observation that it may assume variant histology or immunoprofile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a detailed clinicopathological review of a large retrospective cohort of 30 HN\u2010NUT, aiming to expand its histological and immunohistochemical spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of patients with HN\u2010NUT was 39\u2009years (range\u2009=\u200917\u201386). It affected the sinonasal tract (43%), major salivary glands (20%), thyroid (13%), oral cavity (7%), larynx (7%), neck (7%) and nasopharynx (3%). Although most cases of HN\u2010NUT (63%) contained a component of primitive URC tumour, 53% showed other histological features and 37% lacked a URC component altogether. Variant histological features included basaloid (33%), differentiated squamous\/squamoid (37%), clear cell changes (13%), glandular differentiation (7%) and papillary architecture (10%), which could co\u2010exist. While most HN\u2010NUT were positive for keratins, p63 and p40, occasional cases (5\u20139%) were entirely negative. Immunopositivity for neuroendocrine markers and thyroid transcription factor\u20101 was observed in 33 and 36% of cases, respectively. The outcome of HN\u2010NUT was dismal, with a 3\u2010year disease specific survival of 38%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HN\u2010NUT can affect individuals across a wide age range and arise from various head and neck sites. It exhibits a diverse spectrum of histological features and may be positive for neuroendocrine markers, potentially leading to underdiagnosis. A low threshold to perform NUT\u2010specific tests is necessary to accurately diagnose HN\u2010NUT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15204","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T07:34:21Z","timestamp":1714980861000},"page":"317-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0001","authenticated-orcid":false,"given":"Kartik","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elan","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Sinai Health System  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-8946","authenticated-orcid":false,"given":"Snjezana","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Weinreb","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan C","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Sinai Health System  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"MacMillan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Sinai Health System  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Katabi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Magliocca","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University Hospital Midtown  Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Ghossein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4638-9835","authenticated-orcid":false,"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine 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