{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:37:05Z","timestamp":1787798225435,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Decreased oestrogen receptor (ER) expression is a marker of poor prognosis in endometrial carcinomas (EC) of no specific molecular profile (NSMP), but the optimal cut\u2010off to separate high\u2010risk \u2018low ER\u2019 versus low\u2010risk \u2018high ER\u2019 expression has not been defined. Here we characterised the distribution of ER staining in a cohort of ECs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Biopsy specimens from 120 cases of NSMP EC were stained for ER and assigned an Allred score. In 66 additional cases ER staining of matched biopsy and hysterectomy were compared. Twelve of 120 tumours had an Allred score of 0\u20133, including three endometrioid carcinomas (EEA) (one G1, two G3), four clear cell carcinomas (CCC), two mesonephric\u2010like adenocarcinoma (MLA) and one each of: gastric\u2010type adenocarcinoma, carcinosarcoma and endometrial carcinoma NOS. Three had Allred scores of 4\u20135: two MLA and one high\u2010grade carcinoma with yolk sac differentiation. Five had Allred scores of 6: four EEA (one G1, one G2, two G3) and one mixed clear cell and endometrioid carcinoma. The remaining 100 tumours with Allred scores \u2265\u20097 were all EEA (66\u2009G1, 28 G2, five G3 and one grade unknown). Comparing the biopsy versus hysterectomy ER staining (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200966), the results were within a single Allred score point, except two cases with strong diffuse expression in the biopsy (Allred 8) and moderate expression in the hysterectomy (Allred 5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most NSMP ECs (&gt;\u200980%) show high ER expression (Allred score \u2265\u20097). All non\u2010endometrioid carcinomas and a few endometrioid carcinomas had lower ER expression (Allred score \u2264\u20096) or were completely negative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/his.15241","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T23:56:10Z","timestamp":1718754970000},"page":"660-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The spectrum of oestrogen receptor expression in endometrial carcinomas of no specific molecular profile"],"prefix":"10.1111","volume":"85","author":[{"given":"Mona","family":"Alafraidi","sequence":"first","affiliation":[{"name":"Department of Pathology British Columbia Cancer Agency  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3692-8057","authenticated-orcid":false,"given":"Lynn","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-6680","authenticated-orcid":false,"given":"Brooke E.","family":"Howitt","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teri A.","family":"Longacre","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University School of Medicine  Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica N.","family":"McAlpine","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Division of Gynecologic Oncology, Department of Obstetrics and Gynecology University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-1967","authenticated-orcid":false,"given":"Naveena","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-8250","authenticated-orcid":false,"given":"C Blake","family":"Gilks","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8675-916X","authenticated-orcid":false,"given":"Jennifer","family":"Pors","sequence":"additional","affiliation":[{"name":"Department of Pathology British Columbia Cancer Agency  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27317"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24335"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.08.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<2083::AID-CNCR28>3.0.CO;2-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.04.043"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2021.03.031"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.10.032"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100085"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02141-0"},{"key":"e_1_2_9_12_1","unstructured":"CrothersBA HarikLR BartleyANet\u00a0al.Template for reporting results of biomarker testing of specimens from patients with carcinoma of gynecologic origin.2023."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.82"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2878"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00265"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000451"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2022-004039"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2023.41.16_suppl.TPS5632"},{"key":"e_1_2_9_19_1","unstructured":"Canadian Cancer Trials Group.Adjuvant therapy in POLE\u2010mutated and p53\u2010wildtype\/NSMP early stage endometrial cancer RAINBO BLUE & TAPER. Identifier NCT05640999.https:\/\/classic.clinicaltrials.gov\/ct2\/show\/NCT05640999."},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2020.12.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00963-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02309"},{"key":"e_1_2_9_23_1","volume-title":"Template for reporting results of biomarker testing of specimens from patients with carcinoma of the breast","author":"Fitzgibbons PL","year":"2022"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2018.12.018"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0199-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.21873\/cgp.20338"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12895"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-019-03123-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3886"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896915611489"},{"key":"e_1_2_9_31_1","first-page":"7012","article-title":"Mesonephric adenocarcinoma of the uterine corpus","volume":"7","author":"Wu H","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-017-0655-y"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000991"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.08.018"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13798"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001193"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31824a72c6"},{"key":"e_1_2_9_38_1","first-page":"1212","article-title":"Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature","volume":"7","author":"Tseng CE","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001142"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.911695"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001401"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12581"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000430"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.50.4.328"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001381"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001473"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2016.07.090"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:44:47Z","timestamp":1727153087000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/his.15241"],"URL":"https:\/\/doi.org\/10.1111\/his.15241","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"2024-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}