{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:50:57Z","timestamp":1787669457119,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Ulcerative colitis\u2010associated neoplasia (UCAN) is characterised by multifocal tumourigenesis. A wide range of metachronous lesions have been reported to occur after endoscopic treatment of UCAN, which suggests the development of sporadic tumours in lesions treated as UCAN. Therefore, we aimed to evaluate differences of immunohistochemistry (IHC) in features and clinicopathological characteristics of intramucosal lesions in patients with ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We examined 35 intramucosal lesions resected for carcinoma or dysplasia by total colectomy from patients with UC and 71 sporadic adenomas (SAs) endoscopically resected from patients without UC. UC lesions were divided into the conventional UCAN group, defined as p53 mutant pattern and\u00a0normal expression of \u03b2\u2010catenin, and the non\u2010conventional UCAN group, defined as the rest. Ki\u201067 distribution, \u03b1\u2010methylacyl\u2010CoA racemase (AMACR) expression and mucin phenotypes were compared using IHC, and clinicopathological characteristics were investigated. Conventional and non\u2010conventional UCAN lesions were located in the left colon and rectum. Relative to the SA lesions, UCAN lesions occurred in much younger patients and exhibited more frequent basal distribution of Ki\u201067 in tumour crypts. Conventional UCAN lesions tended to be non\u2010polyploid and exhibited a higher frequency of normal AMACR expression than SA lesions. UC lesions were heterogeneous\u2014only two of the eight patients with multiple lesions had lesions (both non\u2010conventional UCAN lesions) exhibiting concordant IHC staining features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The basal pattern of Ki\u201067 distribution, normal expression of AMACR and a non\u2010intestinal mucin phenotype were determined as characteristic features suggestive of UCAN. Non\u2010polypoid growth was another a key feature of UCAN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15243","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T10:19:42Z","timestamp":1718965182000},"page":"671-685","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ki\u201067 distribution, \u03b1\u2010methylacyl\u2010CoA racemase <scp>(AMACR)<\/scp> expression and mucin phenotypes are associated with non\u2010polypoid growth in ulcerative colitis\u2010associated neoplasia"],"prefix":"10.1111","volume":"85","author":[{"given":"Soh","family":"Okano","sequence":"first","affiliation":[{"name":"Department of Human Pathology, Graduate School of Medicine Juntendo University  Tokyo Japan"},{"name":"Centre for Inflammatory Bowel Disease, Division of Gastroenterology, Department of Internal Medicine, Tokyo Yamate Medical Centre Japan Community Healthcare Organization  Tokyo 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