{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:50:53Z","timestamp":1790985053544,"version":"4.1.0"},"reference-count":127,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Testicular germ cell tumours (GCT) are divided into three different subtypes (types I\u2013III) regarding to their developmental origin, histological differences and molecular features. Type I GCT develop from disturbed primordial germ cells and most commonly occur in children and young adolescents, which is why they are referred to as prepubertal GCT. Type II GCT develop from a non\u2010invasive germ cell neoplasia <jats:italic>in situ<\/jats:italic> (GCNIS) and show an isochromosome 12p (i12p) or gain of 12p material as a common and characteristic molecular alteration. Type III GCT originate from distorted postpubertal germ cells (e.g. spermatogonia) in adult patients and have changes on chromosome 9 with amplification of the <jats:italic>DMRT1<\/jats:italic> gene. Type I GCT encompass prepubertal\u2010type teratomas and yolk\u2010sac tumours (YST). Type II GCT include seminoma, embryonal carcinoma, choriocarcinoma, postpubertal\u2010type teratoma and postpubertal\u2010type YST. Types I and II GCT both show similar morphology, but are separated from each other by the detection of a GCNIS and an i12p in type II GCT. For type II GCT it is especially important to detect non\u2010seminomatous elements, as these tumours have a worse biological behaviour and need a different treatment to seminomas. In contrast to types I and II GCT, type III tumours are equivalent to spermatocytic tumours and usually occur in elderly men, with few exceptions in young adults. The development of types I and II GCT seems to depend not upon driver mutations, but rather on changes in the epigenetic landscape. Furthermore, different pluripotency associated factors (e.g. OCT3\/4, SOX2, SOX17) play a crucial role in GCT development and can be used as immunohistochemical markers allowing to distinguish the different subtypes from each other in morphologically challenging tissue specimens. Especially in metastatic sites, a morphological and immunohistochemical diagnostic algorithm is important to detect small subpopulations of each non\u2010seminomatous GCT subtype, which are associated with a poorer prognosis and need a different treatment. Furthermore, primary extragonadal GCT of the retroperitoneum or mediastinum develop from misguided germ cells during embryonic development, and might be challenging to detect in small tissue biopsies due to their rarity at corresponding sites. This review article summarises the pathobiological and developmental aspects of the three different types of testicular GCT that can be helpful in the histopathological examination of tumour specimens by pathologists.<\/jats:p>","DOI":"10.1111\/his.15249","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T23:25:58Z","timestamp":1719271558000},"page":"701-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Pathogenesis and pathobiology of testicular germ cell tumours: a view from a developmental biological perspective with guidelines for pathological diagnostics"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-2289","authenticated-orcid":false,"given":"Alexander","family":"Fichtner","sequence":"first","affiliation":[{"name":"Institute of Pathology, University Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-845X","authenticated-orcid":false,"given":"Daniel","family":"Nettersheim","sequence":"additional","affiliation":[{"name":"Department of Urology, Urological Research Laboratory, Translational UroOncology Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"Center for Integrated Oncology Aachen, Bonn Cologne D\u00fcsseldorf (CIO ABCD), Lighthouse Project: Germ Cell Tumours  D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-6527","authenticated-orcid":false,"given":"Felix","family":"Bremmer","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Medical Center  G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012390"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-04009-z"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-019-0178-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12958"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy217"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-019-0404-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800415)45:8<2169::AID-CNCR2820450827>3.0.CO;2-U"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.288"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001001"},{"key":"e_1_2_7_14_1","first-page":"2350","article-title":"Spermatocytic seminoma: a 21\u2009years' retrospective study in a tertiary care hospital in Pakistan","volume":"6","author":"Haroon S","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.553850"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.972"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23936"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302051"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-004-0398-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(71)90278-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2023.08.008"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance","volume":"4","author":"Milose JC","year":"2011","journal-title":"Open Access J. Urol."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811115)48:10<2274::AID-CNCR2820481024>3.0.CO;2-W"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.594"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03292"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800715)46:2<380::AID-CNCR2820460228>3.0.CO;2-U"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182a2926e"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1985.68"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01480"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","unstructured":"Application of microRNAs in the diagnosis and monitoring of pediatric germ cell tumors: Kazakh experience: Pediatric Hematology and Oncology: vol. 41 No. 2\u2014get access. Updated 14 February 2024. Available at:https:\/\/www.tandfonline.com\/doi\/full\/https:\/\/doi.org\/10.1080\/08880018.2023.2267607.","DOI":"10.1080\/08880018.2023.2267607"},{"key":"e_1_2_7_32_1","volume-title":"Urinary and male genital tumours [Internet]","author":"WHO Classification of Tumours Editorial Board","year":"2022"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195305)6:3<427::AID-CNCR2820060302>3.0.CO;2-U"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.5644\/ama2006-124.326"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.09.015"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0029-0"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2020.05.009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1568"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)91909-5"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.17.1433"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14258"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02182.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/345686a0"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2332"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.013"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913128809048477"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16222"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-3952(22)04459-3"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2011.01172.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005415"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9903"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050728"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.05.013"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03698-0"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14933"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.1987.tb00176.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2936"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181a13eef"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90171-6"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20011201)92:11<2778::AID-CNCR10125>3.0.CO;2-S"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.183"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der330"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12365"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000017169.26718.5F"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780302"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2919"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01587.x"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-019-0477-1"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-04859-8"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200003000-00003"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-12-400"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000432"},{"key":"e_1_2_7_73_1","first-page":"623","article-title":"Testicular yolk sac carcinoma in infants: natural history in 56 consecutive patients","volume":"203","author":"Pow\u2010Sang J","year":"1985","journal-title":"Prog. Clin. Biol. Res."},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d31f33"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1726::AID-CNCR2820720536>3.0.CO;2-S"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)68313-7"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800749"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2000.16237"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP7MNCNBCRN8NO"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pai.0000173054.83414.22"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.187"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.03.022"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000171"},{"key":"e_1_2_7_84_1","first-page":"463","article-title":"CD30 antigen in embryonal carcinoma and embryogenesis and release of the soluble molecule","volume":"146","author":"Latza U","year":"1995","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14968"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-023-03725-0"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31823c510b"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.09.028"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu375"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000315"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880915)62:6<1113::AID-CNCR2820620614>3.0.CO;2-0"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1629::AID-CNCR2820500828>3.0.CO;2-1"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2019.04.008"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2016.03.010"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000262"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826df1ab"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02425-5"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841101)54:9<1824::AID-CNCR2820540910>3.0.CO;2-J"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910390680"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.019"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.06.024"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318033c7c4"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0352-OA"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000322"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737140.2018.1450630"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.7798"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213815"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_1727_20"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.03.012"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.03.008"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-012-1353-5"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3399"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31827e1e83"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14560"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.09.007"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540205000216"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1988.tb02331.x"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213322.89670.48"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf669"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444271"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2011.01245.x"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2013.04.003"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-012-0069-9"},{"key":"e_1_2_7_124_1","first-page":"440","article-title":"The borderland of embryology and pathology","volume":"26","author":"Willis RA","year":"1950","journal-title":"Bull. N.Y. Acad. Med."},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI143884"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2007.00793.x"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2012.09.003"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15090"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T09:10:18Z","timestamp":1728292218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":127,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/his.15249"],"URL":"https:\/\/doi.org\/10.1111\/his.15249","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"assertion":[{"value":"2024-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}