{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:17:39Z","timestamp":1780352259988,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Low\u2010grade non\u2010intestinal\u2010type sinonasal adenocarcinoma (LGSNAC) is a rare heterogeneous and poorly characterised group of tumours, distinct from intestinal\u2010 and salivary\u2010type neoplasms. Therefore, further characterisation is needed for clearer biological understanding and classification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Clinical, histological and molecular characterisation of four cases of biphasic, low\u2010grade adenocarcinomas of the sinonasal tract was performed. All patients were male, aged between 48 and 78\u2009years, who presented with polypoid masses in the nasal cavity. Microscopically, virtually all tumours were dominated by tubulo\u2010glandular biphasic patterns, microcystic, focal (micro)papillary, oncocytic or basaloid features. Immunohistochemical staining confirmed biphasic differentiation with an outer layer of myoepithelial cells. Molecular profiling revealed <jats:italic>HRAS<\/jats:italic> (p.G13R, p.Q61R) mutations, and concomitant <jats:italic>AKT1<\/jats:italic> (p.E17K, p.Q79R) mutations in two cases. Two cases showed potential <jats:italic>in\u2010situ<\/jats:italic>\/precursor lesions adjacent to the tumour. Follow\u2010up periods ranged from 1 to 30\u2009months, with one case relapsing locally after 12 and &gt;\u200920\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study further corroborates a distinct biphasic low\u2010grade neoplasm of the sinonasal tract with seromucinous differentiation. Although morphological and molecular features overlap with salivary gland epithelial\u2013myoepithelial carcinoma, several arguments favour categorising these tumours within the spectrum of LGSNAC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15251","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T23:25:12Z","timestamp":1719271512000},"page":"899-908","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Expanding the spectrum of low\u2010grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating <i>HRAS\/AKT1<\/i> mutations"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8335-8731","authenticated-orcid":false,"given":"Viktoria S","family":"Hadnagy","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"Pathologie Laenggasse  Ittigen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"R\u00f6ssle","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Lucerne Cantonal Hospital  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dubach","sequence":"additional","affiliation":[{"name":"ENT Department, Buergerspital Solothurn  Solothurn Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunther","family":"Pabst","sequence":"additional","affiliation":[{"name":"Division of Otorhinolaryngology\u2014Head and Neck Surgery Lucerne Cantonal Hospital  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kotulova","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weder","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital Bern University Hospital, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Inselspital University Hospital Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth J","family":"Rushing","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Lucerne Cantonal Hospital  Lucerne Switzerland"},{"name":"Medica Laboratory Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holzmann","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00fcllner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Zurich\/University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra N","family":"Freiberger","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-3456","authenticated-orcid":false,"given":"Niels J","family":"Rupp","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital Zurich  Zurich Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Who classification of tumours editorial board.Head and neck tumours [internet; beta version ahead of print].Lyon (France):International Agency for Research on Cancer 2022[cited 2024 03 09]. 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