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This review summarizes nonneoplastic sclerosing lesions such as radial scar\/complex sclerosing lesion, sclerosing adenosis, sclerosing intraductal papilloma, sclerosing variants of ductal adenoma and nipple adenoma, and fibroadenoma with extensive sclerosis, including their clinical presentation, characteristic morphology, differential diagnostic considerations, appropriate immunohistochemical work\u2010up, when needed, and the clinical significance. In addition, atypical or neoplastic\u00a0entities (such as atypical ductal hyperplasia, ductal carcinoma <jats:italic>in situ,<\/jats:italic> low\u2010grade adenosquamous carcinoma, and fibromatosis\u2010like metaplastic carcinoma) that can involve these sclerosing lesions are also briefly discussed.<\/jats:p>","DOI":"10.1111\/his.15252","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T23:25:29Z","timestamp":1719271529000},"page":"383-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Nonneoplastic and neoplastic sclerosing lesions of the breast"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6125-5865","authenticated-orcid":false,"given":"Gulisa","family":"Turashvili","sequence":"first","affiliation":[{"name":"Department of Pathology Massachusetts General Hospital, Harvard Medical School  Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"368","volume-title":"Who classification of tumours: breast tumours","year":"2019"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2958-y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000393"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2003.10.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.12.003"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-207097"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14799"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181dd60d3"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21730"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044383"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.127"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.179.5.1791179"},{"key":"e_1_2_12_14_1","first-page":"72","article-title":"Management of radial scars found at percutaneous breast biopsy","volume":"57","author":"Becker L","year":"2006","journal-title":"Can. 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