{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:45:04Z","timestamp":1790891104407,"version":"4.1.0"},"reference-count":119,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Histopathology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Urothelial carcinoma (UC) demonstrates significant molecular and histologic heterogeneity. The WHO 2022 classification has hinted at adding molecular signatures to the morphologic diagnosis. As morphology and associated molecular repertoire may potentially translate to choices of and response to therapy and relapse rate, broader acceptability of recognizing these key features among uropathologists is needed. This prompted an international survey to ascertain the practice patterns in classical\/subtype UC among uropathologists across the globe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A survey instrument was shared among 98 uropathologists using SurveyMonkey software. Anonymized respondent data were analysed. The response rate was 85%. A majority were in concordance with the profiles of luminal (93%) and basal (82%) types. Opinion on the <jats:italic>FGFR3<\/jats:italic> testing platform was variable. While 95% concurred that <jats:italic>TERT<\/jats:italic> promoter mutation is the key driver in UC, 72% had the opinion that <jats:italic>APOBEC<\/jats:italic> mutagenesis is the main signature in muscle invasive bladder cancer (MIBC). Uropathologists have divergent opinions on MIBC and <jats:italic>ERCC2<\/jats:italic> mutations. Among the participants, 94% would quantify aggressive micropapillary and sarcomatoid histology, while 88% would reevaluate another transurethral resection of the bladder tumour specimen in nonmuscle invasive tumour with micropapillary, small cell, or sarcomatoid histology. A leading number agreed to specific molecular signatures of micropapillary (93%), plasmacytoid (97%), and small cell (86%) subtypes. Ninety\u2010six percent of participants agreed that a small\u2010cell component portends a more aggressive course and should be treated with neoadjuvant chemotherapy and 63% would perform <jats:italic>HER2\/neu<\/jats:italic> testing only on oncologist's request in advanced tumours. Ninety percent agreed that microsatellite instability testing, although not a standard protocol, should be considered in young patients with upper tract UC. Eighty\u2010six percent agreed that UC with high tumour mutational burden would be a better candidate for immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the era of precision medicine, enhanced understanding of molecular heterogeneity of UC will contribute to better therapeutic options, novel biomarker discovery, innovative management protocols, and outcomes. Our survey provides a broad perspective of pathologists' perceptions and experience regarding incorporation of histomolecular approaches to \u201cpersonalize\u201d therapy. Due to variable clinical adoption, there is a need for additional data using uniform study criteria. This will drive generation of best practice guidelines in this area for widespread and consistent clinical utility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/his.15287","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T04:09:35Z","timestamp":1722312575000},"page":"748-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Advances, recognition, and interpretation of molecular heterogeneity among conventional and subtype histology of urothelial carcinoma (UC): a survey among urologic pathologists and comprehensive review of the literature"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-8009","authenticated-orcid":false,"given":"Anandi","family":"Lobo","sequence":"first","affiliation":[{"name":"Department of Pathology Kapoor Centre of Urology and Pathology  Raipur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9603-6731","authenticated-orcid":false,"given":"Katrina","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University Health  Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8817-6331","authenticated-orcid":false,"given":"Andres M","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Pathology Indiana University Health  Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmut","family":"Akgul","sequence":"additional","affiliation":[{"name":"Department of Pathology Albany Medical Center  Albany USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit K","family":"Adhya","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikmat A","family":"Al\u2010Ahmadie","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-8751","authenticated-orcid":false,"given":"Khaleel I","family":"Al\u2010Obaidy","sequence":"additional","affiliation":[{"name":"Department of Pathology Henry Ford Health System  Detroit USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology Alpert Medical School of Brown University  Providence USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahul B","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pathology Keck School of Medicine of the University of Southern California  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Aron","sequence":"additional","affiliation":[{"name":"Department of Pathology Keck School of Medicine of the University of Southern California  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie L","family":"Balzer","sequence":"additional","affiliation":[{"name":"Department of Pathology Cedars\u2010Sinai Medical Center  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupanita","family":"Biswal","sequence":"additional","affiliation":[{"name":"Department of Pathology Bagchi Sri Shankara Cancer Hospital  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashish","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology SUM Ultimate Medicare Hospital  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Browning","sequence":"additional","affiliation":[{"name":"Department of Pathology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Kalyani India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cima","sequence":"additional","affiliation":[{"name":"Department of Pathology Santa Chiara Hospital of Trento  Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Cimadamore","sequence":"additional","affiliation":[{"name":"Department of Pathology Molecular Medicine and Cell Therapy Foundation c\/o Polytechnic University of the Marche Region  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3588-9888","authenticated-orcid":false,"given":"Sangeeta","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasreman","family":"Dhillon","sequence":"additional","affiliation":[{"name":"Department of Pathology Moffitt Cancer Center  Tampa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Deshwal","sequence":"additional","affiliation":[{"name":"Department of Pathology ESI Hospital  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo G","family":"Diego","sequence":"additional","affiliation":[{"name":"Department of Pathology University Gregorio Mara\u00f1on Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Diwaker","sequence":"additional","affiliation":[{"name":"Department of Pathology University College of Medical Sciences  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7968-1846","authenticated-orcid":false,"given":"Laurence A","family":"Galea","sequence":"additional","affiliation":[{"name":"Department of Pathology Melbourne Pathology  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Magi\u2010Galluzzi","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Alabama at Birmingham  Birmingham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0326-3207","authenticated-orcid":false,"given":"Giovanna A","family":"Giannico","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California \u2013 Irvine  Irvine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilesh S","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology Henry Ford Health System  Detroit USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Pathology University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-8564","authenticated-orcid":false,"given":"Michelle S","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Pathology Brigham and Women's Hospital  Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A","family":"Iczkowski","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California \u2013 Davis  Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samriti","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekta","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpy","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Pathology Advanced Medical and Research Institute  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Kandukuri","sequence":"additional","affiliation":[{"name":"Department of Pathology Keck School of Medicine of the University of Southern California  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Sui","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-1748","authenticated-orcid":false,"given":"Oleksandr N","family":"Kryvenko","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Miami Miller School of Medicine  Miami USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramani M","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology Dane Diagnostics  Palakkad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Raebareli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi P","family":"Kunju","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levente","family":"Kuthi","sequence":"additional","affiliation":[{"name":"Department of Pathology Albert Szent\u2010Gy\u00f6rgyi Medical School, University of Szeged  Szeged Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Pathology Portuguese Oncology Institute \u2013 Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose I","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Pathology Cruces University Hospital  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Luthringer","sequence":"additional","affiliation":[{"name":"Department of Pathology Cedars\u2010Sinai Medical Center  Los Angeles USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Maclean","sequence":"additional","affiliation":[{"name":"Department of Pathology Douglass Hanly Moir Pathology  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Manini","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mannan","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G","family":"Martos","sequence":"additional","affiliation":[{"name":"Department of Pathology University Gregorio Mara\u00f1on Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6955-8884","authenticated-orcid":false,"given":"Rohit","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan  Ann Arbor USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4140-0671","authenticated-orcid":false,"given":"Santosh","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pathology Tata Memorial Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritinanda","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Moch","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Montironi","sequence":"additional","affiliation":[{"name":"Department of Pathology Molecular Medicine and Cell Therapy Foundation c\/o Polytechnic University of the Marche Region  Ancona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manas R","family":"Baisakh","sequence":"additional","affiliation":[{"name":"Department of Pathology Prolife Diagnostics  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George J","family":"Netto","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pennsylvania  Philadelphia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovelesh K","family":"Nigam","sequence":"additional","affiliation":[{"name":"Department of Pathology Institute of Kidney Diseases and Research Center  Ahmedabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-8134","authenticated-orcid":false,"given":"Adeboye O","family":"Osunkoya","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University School of Medicine  Atlanta USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pagliuca","sequence":"additional","affiliation":[{"name":"Department of Pathology Universit\u00e0 degliStudidella Campania Luigi Vanvitelli  Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladell P","family":"Paner","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago  Chicago USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Panizo","sequence":"additional","affiliation":[{"name":"Department of Pathology Complejo Hospitalario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil V","family":"Parwani","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center  Columbus USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M","family":"Picken","sequence":"additional","affiliation":[{"name":"Department of Pathology Loyola University Medical Center  Hines USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Prendeville","sequence":"additional","affiliation":[{"name":"Department of Pathology University Health Network, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-7272","authenticated-orcid":false,"given":"Christopher G","family":"Przybycin","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvendu","family":"Purkait","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4173-6300","authenticated-orcid":false,"given":"Francisco J","family":"Queipo","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario de A Coruna  A Coruna Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-548X","authenticated-orcid":false,"given":"B Vishal","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology Basavatarakam Indo\u2010American Cancer Hospital and Research Institute  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas MD Anderson Cancer Center  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sankalp","family":"Sancheti","sequence":"additional","affiliation":[{"name":"Department of Pathology Homi Bhabha Cancer Hospital  Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur R","family":"Sangoi","sequence":"additional","affiliation":[{"name":"Department of Pathology Stanford University  Stanford USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Sardana","sequence":"additional","affiliation":[{"name":"Department of Pathology Sardana Laboratories  Jalandhar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Satturwar","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center  Columbus USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajal B","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center  Dallas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallika","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Sirohi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California  San Francisco USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-4607","authenticated-orcid":false,"given":"Steven C","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology Virginia Commonwealth University School of Medicine  Richmond USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Pathology Muljibhai Patel Urological Hospital  Nadiad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Pathology Sri Ramachandra Institute of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Pathology Apollo Hospitals  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-9638","authenticated-orcid":false,"given":"Maria","family":"Tretiakova","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Washington  Seattle USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-8846","authenticated-orcid":false,"given":"Kiril","family":"Trpkov","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Calgary  Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorka","family":"Mu\u00f1izUnamunzaga","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital San Jorge  San Juan Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-1460","authenticated-orcid":false,"given":"Sean R","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic  Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-8164","authenticated-orcid":false,"given":"Antonio","family":"Lopez\u2010Beltran","sequence":"additional","affiliation":[{"name":"Department of Pathology, Unit of Anatomical Pathology, Faculty of Medicine Cordoba University  Cordoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pathology Alpert Medical School of Brown University  Providence USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5094-2424","authenticated-orcid":false,"given":"Sambit K","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Pathology CORE Diagnostics  Gurgaon India"},{"name":"Department of Pathology Advanced Medical and Research Institute  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.03.055"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.08.010"},{"key":"e_1_2_10_4_1","unstructured":"Available at:https:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/39\u2010All\u2010cancers\u2010fact\u2010sheet.pdf. (Accessed December 11 2022)."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60491-8"},{"key":"e_1_2_10_6_1","first-page":"394","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Sung H","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13050756"},{"key":"e_1_2_10_8_1","unstructured":"National Comprehensive Cancer Network.Bladder cancer (Version 3.2023).https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/bladderAccessed August 20 2023."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12477"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12965"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29826"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2018.07.011"},{"key":"e_1_2_10_13_1","volume-title":"Urinary and male genital tumors","author":"WHO Classification of Tumors Editorial Board","year":"2022"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.05.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.26"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.08.027"},{"key":"e_1_2_10_17_1","first-page":"92","article-title":"Understanding the molecular pathogenesis and prognostics of bladder cancer: an overview","volume":"28","author":"Zhao M","year":"2016","journal-title":"Chin. J. Cancer Res."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.48"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1586\/era.10.73"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013821"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2014.07.010"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00102"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2011-0471-RA"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092230"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1697"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2073"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3817"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2022.06.005"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2021.04.001"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0001-5"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-16-0003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260200"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.028"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.038"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.1915725"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310522110"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.07.004"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.057"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.08.052"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-020-0304-1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.04.038"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00534"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2702"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2701"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3692"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2520"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.7740"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30219"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-0623"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.2425"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13215500"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2021.03.014"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14082"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0000000000000252"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5230"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1318376111"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-019-02618-5"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.08.036"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.01.009"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3233\/BLC-150037"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0077-T"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.05.013"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4886"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020628"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66747-7"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-020-0960-y"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1215"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-4213"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22126-x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2655"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13696"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010131"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.04.086"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.05.040"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.10.008"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.04.020"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.006"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0976-0"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.03.033"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2013.01.003"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00423-4"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199412000-00005"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800166"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3897-x"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1992"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.69"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.201"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-015-1729-4"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2014.01.020"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)00423-4"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1986-x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3503"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25700"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318186c45e"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.11.084"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.12.035"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14664"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0192-5"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.06.050"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4045"},{"key":"e_1_2_10_102_1","unstructured":"Centers for Medicare & Medicaid Services.Clinical laboratory improvement amendments (CLIA).2022https:\/\/www.cms.gov\/regulations\u2010andguidance\/legislation\/clia\/index.html."},{"key":"e_1_2_10_103_1","unstructured":"U.S. Food & Drug Administration.FDA grants accelerated approval to erdafitinib for metastatic urothelial carcinoma.2019https:\/\/www.fda.gov\/drugs\/resources\u2010information\u2010approved\u2010drugs\/fdagrants\u2010accelerated\u2010approval\u2010erdafitinib\u2010metastatic\u2010urothelial\u2010carcinoma."},{"key":"e_1_2_10_104_1","unstructured":"U.S. Food and Drug Administration.List of cleared or approved companion diagnostic devices (in vitro and imaging tools).2022https:\/\/www.fda.gov\/medical\u2010devices\/vitro\u2010diagnostics\/listcleared\u2010or\u2010approved\u2010companion\u2010diagnostic\u2010devices\u2010vitro\u2010and\u2010imagingtools."},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29030117"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2020.11.004"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10755"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30445-9"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-0327"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817323"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01140"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01395"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.08.002"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOU.0000000000000340"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1011885"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102351"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0866-z"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.653491"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8738"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0331-CP"}],"container-title":["Histopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/his.15287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T09:10:28Z","timestamp":1728292228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/his.15287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,29]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/his.15287"],"URL":"https:\/\/doi.org\/10.1111\/his.15287","archive":["Portico"],"relation":{},"ISSN":["0309-0167","1365-2559"],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,29]]},"assertion":[{"value":"2024-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}